Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
  Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login  
  Home Print this page Email this page Small font sizeDefault font sizeIncrease font size Users Online: 1915       
REVIEW ARTICLE
Year : 2016  |  Volume : 144  |  Issue : 3  |  Page : 339-347

Cartilage tissue engineering: Role of mesenchymal stem cells along with growth factors & scaffolds


1 Division of Surgery, Modular Laboratory Building, Indian Veterinary Research Institute, Izatnagar; Clinical Veterinary Services Complex, Faculty of Veterinary Sciences & Animal Husbandry, Shuhama, Sher-e-Kashmir University of Agricultural Sciences & Technology, Srinagar, India
2 Division of Surgery, Modular Laboratory Building, Indian Veterinary Research Institute, Izatnagar, India
3 Division of Physiology & Climatology, Indian Veterinary Research Institute, Izatnagar, India

Correspondence Address:
Amarpal
Division of Surgery, Indian Veterinary Research Institute, Izatnagar 243 122, Uttar Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-5916.198724

Rights and Permissions

Articular cartilage injury poses a major challenge for both the patient and orthopaedician. Articular cartilage defects once formed do not regenerate spontaneously, rather replaced by fibrocartilage which is weaker in mechanical competence than the normal hyaline cartilage. Mesenchymal stem cells (MSCs) along with different growth factors and scaffolds are currently incorporated in tissue engineering to overcome the deficiencies associated with currently available surgical methods and to facilitate cartilage healing. MSCs, being readily available with a potential to differentiate into chondrocytes which are enhanced by the application of different growth factors, are considered for effective repair of articular cartilage after injury. However, therapeutic application of MSCs and growth factors for cartilage repair remains in its infancy, with no comparative clinical study to that of the other surgical techniques. The present review covers the role of MSCs, growth factors and scaffolds for the repair of articular cartilage injury.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1938    
    Printed6    
    Emailed0    
    PDF Downloaded548    
    Comments [Add]    
    Cited by others 18    

Recommend this journal