|Year : 2016 | Volume
| Issue : 5 | Page : 545-551
Why is the oral cholera vaccine not considered an option for prevention of cholera in India? Analysis of possible reasons
Sanjukta Sen Gupta1, Kaushik Bharati1, Dipika Sur1, Ajay Khera2, NK Ganguly1, G Balakrish Nair1
1 Translational Health Science & Technology Institute, Faridabad 121 001, Haryana, India
2 Ministry of Health & Family Welfare, Government of India, New Delhi 110 011, India
|Date of Web Publication||28-Jul-2016|
G Balakrish Nair
Translational Health Science & Technology Institute, Faridabad 121 001, Haryana
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Gupta SS, Bharati K, Sur D, Khera A, Ganguly N K, Nair G B. Why is the oral cholera vaccine not considered an option for prevention of cholera in India? Analysis of possible reasons. Indian J Med Res 2016;143:545-51
|How to cite this URL:|
Gupta SS, Bharati K, Sur D, Khera A, Ganguly N K, Nair G B. Why is the oral cholera vaccine not considered an option for prevention of cholera in India? Analysis of possible reasons. Indian J Med Res [serial online] 2016 [cited 2021 May 6];143:545-51. Available from: https://www.ijmr.org.in/text.asp?2016/143/5/545/187102
Cholera has been for many centuries a permanent feature of life in the slums and poverty-stricken villages in India, particularly in the eastern regions of the country. In this region outbreaks have occurred frequently since the early 1800s. The first six cholera pandemics originated from this geographical region while the seventh and ongoing pandemic originated in 1961 from Sulawasi in Indonesia. Most recent evidence indicates that within the seventh cholera pandemic two of the three waves of the El Tor biotype of Vibrio cholerae originated from the Gangetic delta off the Bay of Bengal.
Recent estimates have shown 2.9 million cases and 95,000 deaths occurring annually in cholera endemic countries worldwide. Of this, India accounts for 675,188 cases and 20,256 deaths. In addition, an issue of concern is that 65-86 per cent of the isolates have been found to be resistant to the commonly used antimicrobials and their prevalence is concentrated in the lowest quintile of wealth.
Although access to clean water for drinking and hand washing and good sanitation system form the pillars of cholera prevention and control, availability of a reasonably priced, safe and effective vaccine provides an additional intervention for quick deployment and protection against the disease. One of the WHO prequalified oral cholera vaccine (OCV) is manufactured in India and has been found safe and effective in endemic as well as epidemic situations in countries around the globe. Although this vaccine is in use in the private health care system in India, it has not been considered for use in the national immunization programme of the country. Here we analyze the possible reasons why OCVs have not been used in India in the national immunization programme, through which these vaccines could be made available to people who need it the most.
Cholera: the disease
V. cholera is transmitted through contaminated water and food and is associated with poverty, poor hygiene, and inadequate sanitation. The disease typically begins with an acute attack of watery diarrhoea and copious vomiting, rapidly followed by dehydration and in the absence of treatment, renal failure and death can occur within a matter of 3 to 4 h. About 80 per cent of cholera episodes are of mild-to-moderate severity. Cholera usually responds to antibiotics and prompt administration of oral rehydration salts (ORS) to replace lost fluids. In the past, before the advent of fluid replacement therapy, up to 50 per cent of infected people died from the disease. Despite the case fatality reducing to less than 5 per cent, on a global average, the incidence of cholera remains the same in the past decades. Since the average duration of an episode of paediatric diarrhoea is 3.1 days, and approximately a quarter of those are of mild presentation, caregivers are reluctant to seek any form of treatment. Although ORS is recommended for all episodes at the population level, the rate of its usage is only 75 per cent at the maximum globally. In India, the utilization of ORS hovers around 23 to 42 per cent. In severe cases, intravenous (iv) infusion of fluids is mandatory, for which hospitalization is required is also often out of reach of the affected population.
Water, sanitation and hygiene (WaSH) in prevention of cholera
Provision of clean drinking water, improved sanitation and knowledge about hygiene form the mainstay of prevention of any disease transmitted by the faeco-oral route. These interventions have been used as long-term measures for cholera prevention and control. However, these are resource-intensive as well as time-consuming to implement. Despite heavy investments in these interventions globally, a significant proportion of population still remains unreached. Although global target for Millennium Development Goals (MDG) for drinking-water has been met in 2010, only 147 countries have met the goal as of 2015. disparities exist between those living in rural and urban areas and pose a challenge to achieving equity in health. Moreover, available information about drinking water safety is incomplete, as systematic testing of the quality of water, both microbial and chemical, at a national level in these countries is prohibitively expensive and logistically complicated.
Unplanned migration from rural to urban areas in search of employment, particularly in the unorganized sector, is leading to a changing pattern of demographics. This causes overcrowding in the urban slums, where density of population is ever exceeding the available resources. Susceptibility to diarrhoeal diseases like cholera is aggravated by scarcity of potable water and lack of proper sanitation in such urban slums.
Another factor that complicates issues in this case is the practice of open defaecation. Approximately 15 per cent of world's population i.e. 1.1 billion people practice open-defaecation, often contaminating the sources of drinking water. India has almost 50 per cent of its rural population defaecating in the open, which amounts to nearly 60 per cent of the global total.
Vaccines for cholera have a short-term effect (3-5 years), but are easily-deployable and evoke an immediate response, thus making them remarkable public health tools in both endemic as well as epidemic situations,. The realization that a vaccine could prevent the disease, originated in the days of Robert Koch, who is credited with the discovery of cholera, the “comma” bacillus. Since then, a number of injectable whole cell based vaccines have been developed. However, these parenteral cholera vaccines were discontinued by WHO in the early 1970s, because of the realization that the injectable cholera vaccine was more painful than protective. The parenteral vaccine conferred 30-50 per cent protection for 3-5 months after intramuscular (im) or subcutaneous (sc) administration and caused local erythema, pain, fever, headache and malaise.
Currently, two oral cholera vaccines are WHO prequalified and are available. Of these, Dukoral® made from the inactivated whole-cell V. cholera with a recombinant fragment (B subunit) of the cholera toxin is manufactured by SBL Vaccin AB (owned by Crucell, Sweden AB). The latter component conferred additional protection against enterotoxigenic Escherichia More Details coli (ETEC) apart from cholera,. Field trials in Bangladesh, Mozambique, and Peru found the vaccine to be safe and effective. But the vaccine has some shortcomings. First, it requires two doses given one week apart and requires to be taken with a buffer solution; the two factors that complicate its use, particularly in epidemic situation. Second, its protective capability takes about three weeks to develop after administration of the first dose. Protection is highest during the first six months after vaccination but lasts for up to three years. Third, it is effective only against the V. cholera O1 serogroup, which until 1992, was the only serogroup causing cholera. But in 1992 a second serogroup, O13919-21 was identified as the cause of epidemics in Bangladesh and India, and has since been implicated in a growing number of outbreaks in Asia,.
The second vaccine, reformulated by the International Vaccine Institute (IVI), Korea, is now manufactured by Shantha Biotech (a Sanofi Company), based in Hyderabad and is marketed as ShancholTM. This vaccine is bivalent (BivWC) as it incorporates newly emerged O139 serogroup apart from O1. Unlike its predecessor, this vaccine is cheap (120 per dose, as opposed to 320 for Dukoral®) and effective, with a vaccine efficacy of 65 per cent lasting for up to five years post-vaccination and possibly longer. Unlike Dukoral®, ShancholTM does not require buffer thereby making it more acceptable for infants and children. Following its licensure in India, feasibility and costs of a local vaccination campaign using government health staff, resources, and logistics for Shanchol™ has been demonstrated in Odisha. This demonstration project showed reduction in cholera cases by 69 per cent in the area over next two years. The delivery of the vaccine is feasible in a public health system and there is little difference between overall protective effectiveness of the vaccine alone, as with other interventions like washing hands and using chlorinated water.
Epidemics of cholera occur with regularity in India, among the marginalized people especially in remote areas where the social, epidemiological and ecological conditions continue to favour the occurrence of cholera. Therefore, it is enigmatic that in a country like India where the disease occurs in sporadic, endemic and epidemic proportions and where a safe efficacious oral cholera vaccine is available, vaccination against cholera is not considered an option in the country's public health programme. Obviously, there is a gap in our understanding as to why an available vaccine is not being used. We have critically analyzed the possible reasons for this enigma for deployment and uptake at different levels.
The possible reasons are as follows:
1 (i). Underreporting: Cholera continues to be grossly underreported in India. The extent of underreporting can be illustrated by comparing the number of cholera cases reported by India to the WHO ([Table I]) and the number of cholera cases admitted to the Infectious Diseases (ID) Hospital in Kolkata ([Table II]). Of note, is the fact that these hospitalization figures are for a single hospital in the country, which is more than the figures reported to WHO for the entire country for the entire year. Thus much lower numbers of cholera cases are recorded in the WHO database than that actually occur in the country. The major source of data for the Government is the Integrated Disease Surveillance Project (IDSP), which is a government of India initiative. This originates at the State level and is compiled at the national level. However, there are several reasons for which cholera is underreported in this surveillance. The major cause for underreporting by clinicians is the non-availability of a rapid diagnostic test (RDT) for cholera at the point of care, as a result most of the cholera cases get reported as “acute diarrhoeal disease” (by a factor of 6). In addition, inconsistencies in case-definition also add to the dilemma. The underreported data are being used by the decision makers in the country, leading to the perception that the cholera does not exist in the country. Efforts must be made to obtain a realistic idea of the burden of cholera in India from available data and from robust estimations.
|Table II: Actual and estimated cholera cases at the Infectious Diseases Hospital, Kolkata, 2007-2010|
Click here to view
1 (ii). The differing clinical characteristics of cholera: From the clinical spectrum of chlolera, it is evident that the classical rice water stool is present only in cases of severe infection (cholera gravis), while in most mild infections, it is the loose or watery stool that is indistinguishable from other causes of diarrhoea. In asymptomatic infections, the stool is essentially normal. If we look at the latest figures of cholera and acute diarrhoeal disease cases from the National Health Profile of India 2012, it is quite evident that the number of cholera cases is miniscule when compared to the number of cases due to acute diarrhoeal diseases. Ironically in states like Odisha, where cholera is known to be endemic, there is no representation of cholera cases for 2012, although there are 740,000 cases of acute diarrhoeal disease with 235 deaths.
1 (iii). Misperception of cholera among physicians and lay persons: The consistent underreporting of cholera in India has a snowballing effect, resulting in misperception of cholera among clinicians in the country. This could be because most of the clinicians, especially the ones trained / practicing in non-endemic areas or who have an affluent clientage, do not recognize a case of cholera. A concerted effort from different stakeholders is needed to inform the practicing physicians of the disease, its sub-geographic persistence and fast spread to other areas of the country. Most of the acute diarrhoeal cases go to primary health centers (PHCs) for treatment, rather than being treated by private medical practitioners, especially in rural areas. In urban settings in endemic areas, it is the hospitals attached to medical colleges that cater to the acute diarrhoeal cases. PHCs in endemic areas do not have accurate and sensitive diagnostic tests; and where these are available, personnel are not trained to use them.
1 (iv). Political and socio-economic considerations: Outbreaks of cholera are rightly equated to breach in sanitation and lack of safe drinking water, which reflects poorly on the state health machinery. Consequently there is, at times, a tendency to push the episode under the carpet. Apart from the technical reasons, the gross underestimation could be attributed to other reasons, including the stigma attached to cholera in the society, for the fear of economic sanctions that follow. This situation continues despite the fact that trade embargoes have been lifted as far back as 2002. Such an important decision about the lifting of embargoes needs to be properly disseminated to a wider audience, ranging from key decision makers, on the one hand, to the layman on the other. Moreover, in India, V. cholerae is still considered a pathogen only for outbreak investigations, rather than part of national disease surveillance network.
1 (v). Lack of awareness in the community: The quantum of demand of any intervention from its potential users forms a very important criterion for decision making for its introduction in a public programme. A deeper inquiry into the handicaps at the patient level is also required to understand why a strong demand for OCV has not been generated so far. The ignorance about the disease and available preventive measures remains the major causes. The families that get affected in endemic areas are generally poor with a median monthly income of 4280 for a family of five members,. The onslaught of diarrhoeal diseases like cholera, coupled with poverty, forms a vicious cycle from which there is little hope of escape. Despite improvements in access to health care, inequities are related to socio-economic status, geography and gender and are compounded by high out-of-pocket expenditures, with more than three-quarters of the increasing financial burden of health care being met by households. Health care expenditures exacerbate poverty, with about 39 million additional people falling into poverty every year as a result of such expenditure.
There is a lack of awareness about availability of effective prevention measures like an OCV and its cost among the users. The new OCV is available at the cost of 120 per dose, which amounts to 1.24 per cent of the income of the potential users as compared to 21 per cent for the cost of treatment. However, those who are informed about the usefulness of a cholera vaccine are ready to receive the vaccine only if it is provided free.
2. Paradox at the vaccine manufacture and supply level: The continuous and adequate supply of the vaccine is a pre-requisite for it to be introduced in a publicly funded programme. The three steps that need to follow in tandem in order to encourage new manufacturers are (i) assessment of demand in India and around the globe, (ii) assessing the willingness of new vaccine manufacturers in developing countries to receive the technology and invest in manufacturing this vaccine, and (iii) have incentives in place to mitigate the risk to new manufacturers.
The vaccine ShancholTM has been licensed in India since February 2009; and was WHO prequalified in September 2011, following its use in the Haiti outbreak. GAVI, the Vaccine Alliance (previously called Global Alliance for Vaccines and Immunization) has pledged support for 20 million doses for the global stockpile over the next five years. Lack of a firm demand fails to generate enough market-pull for companies to remain interested in the business. On the other hand, depending on only one producer for global supply of any vaccine is a significant risk for programmes, because of wavering business goals of companies. This situation is likely to improve with another OCV from Eubiologics in Korea (EuviChol) getting WHO prequalified.
3. The missing champion for cholera in India: Several successful national public health programmes around the globe have had “Champions” behind them. Good examples include Gary Valenciano, a UNICEF National Ambassador for ORS in the Philippines and Paul Farmer for the use of OCV in Haiti. in India a “Champion” for cholera vaccine is still missing.
4. New advocacy and policy initiatives: There are a number of initiatives, where global strategies for cholera vaccination have been discussed, deliberated, and gaps and evidence identified. The Initiative against Diarrheal and Enteric diseases in Asia (IDEA) is one such initiative (http://www.idea-asia.info). This initiative, headquartered in Lyon, France, includes experts from eight cholera-endemic countries of Asia, who meet annually to take forward the agenda of cholera, both globally, as well as regionally. So far, four meetings have been convened in Chiang Mai, Thailand; Yogyakarta, Indonesia; Tagaytay City, the Philippines and New Delhi, India.
The Coalition for Cholera Prevention and Control (CCPC) is another new initiative that was established in 2011 through a 2-year conference grant from the Bill and Melinda Gates Foundation (BMGF) awarded to Task Force for Global Health (TFGH) and Harvard Medical School/Partners in Health (HMS/PIH) (http://choleracoalition.org). The CCPC is a coalition of partners focused on developing a comprehensive strategy for cholera prevention and control, including appropriate use of OCV in both endemic and epidemic settings. Several meetings have been held in the interim period since its inception and currently, the coalition members are working to gain endorsement of a strategy and mobilize resources for implementation of OCV.
The WHO Strategic Advisory Group of Experts (SAGE) on Oral Cholera vaccines was established in November 2015 (www.who.int/immunization/policy/sage/sage_wg_cholera_nov2015/en/). Their main objective is to analyse the results of Monitoring and Evaluation (M&E) activities implemented during OCV campaigns with particular focus on communities' acceptability, safety of OCV, vaccine effectiveness in various settings, cost analysis, impact of cholera transmission in endemic and epidemic settings. Further, they are to review evidence and propose recommendations for vaccination strategies, for use of OCV in pregnant and lactating women as well as among travellers and propose potential revisions for endemic settings (“hotspots”) during humanitarian emergencies and during outbreaks.
Another initiative, known as the Stop Cholera or DOVE (Delivering Oral Vaccine Effectively) programme is spearheaded by Johns Hopkins Bloomberg School of Public Health (https://www.stopcholera.org). It includes a strong international team of experts. Its collaborators include the Bill and Melinda Gates Foundation, The African Cholera Surveillance Network (AfriCHOL), International Vaccine Institute, United Nations Children Fund, and the International Federation of Red Cross and Red Crescent Societies, to name a few. It has developed a number of important resources in the area of cholera prevention and control. This programme recommends that the OCV should be a part of comprehensive cholera control strategies.
In the absence of a national surveillance programme for cholera in India, data on burden and effectiveness of OCV in a national immunization programme are being modelled based on data from Bangladesh. Campaign and continuous vaccination targeting all individuals one year and older in 50 per cent in the population is projected to reduce cholera cases by close to 50 and 70 per cent, respectively.
It is quite evident that by looking at a decade long outbreak pattern, West Bengal has reported cholera outbreaks in all 10 years, followed by Maharashtra and Delhi (9 years), then Odisha (7 years). In recent years these outbreaks have spread to newer areas. These data give us a starting point for vaccination campaigns against cholera in India. Importantly, West Bengal seems to be a plausible place to begin vaccination efforts since evidence exists for at least two of three waves of global transmission in the seventh cholera pandemic originating essentially from this state in India,. this will require a concerted and sustained effort on the part of a small group of experts, dedicated specifically for cholera control in the country, to achieve the desired objective.
A cholera expert group has been constituted by the Department of Biotechnology, India with leading authorities in the field to address the issue of introduction of an OCV as an adjunct to other long-term methods such as WaSH in a holistic and well coordinated fashion, which will be time-bound and goal-oriented. Introduction of cholera vaccine piggybacking on the rotavirus vaccine might prove to be more effective from a logistical standpoint. Efforts are ongoing to take this initiative forward so that vaccination against cholera is used in at least one cholera endemic state in India, and serve as a model for other endemic states.
Conflicts of Interest:
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[Table I], [Table II]
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