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REVIEW ARTICLE
Year : 2015  |  Volume : 142  |  Issue : 6  |  Page : 663-674

Individualization of antiretroviral therapy - Pharmacogenomic aspect


Department of Transfusion Transmitted Disease, National Institute of Immunohaematology (ICMR), Mumbai, India

Correspondence Address:
Aruna Shankarkumar
Department of Transfusion Transmitted Disease, National Institute of Immunohaematology (ICMR), 13th floor, New Multistoreyed Building, KEM Hospital campus, Parel, Mumbai 400 012, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-5916.174549

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Combination therapy with three drug regimens for human immunodeficiency virus (HIV) infection significantly suppresses the viral replication. However, this therapeutic impact is restricted by adverse drug events and response in terms of short and long term efficacy. There are multiple factors involved in different responses to antiretrovirals (ARVs) such as age, body weight, disease status, diet and heredity. Pharmacogenomics deals with individual genetic make-up and its role in drug efficacy and toxicity. In depth genetic research has provided evidence to predict the risk of developing certain toxicities for which personalized screening and surveillance protocols may be developed to prevent side effects. Here we describe the use of pharmacogenomics for optimal use of HAART (highly active antiretroviral therapy).


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