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Year : 2014  |  Volume : 140  |  Issue : 5  |  Page : 609-615

Association of matrix metalloproteinase -7 (-181A/G) promoter polymorphism in chronic pancreatitis

1 Institute of Genetics & Hospital for Genetic Diseases, Osmania University, Hyderabad, India
2 Department of Gastroenterology, Gandhi General Hospital, Hyderabad, India
3 Department of Gastroenterology & Osmania General Hospital, Secunderabad, India
4 Department of Genetics, Osmania University, Hyderabad, India

Correspondence Address:
A Venkateshwari
Assistant Professor, Institute of Genetics & Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500 016, Telangana
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Source of Support: None, Conflict of Interest: None

PMID: 25579141

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Background & objectives: Chronic pancreatitis is progressive and irreversible destruction of the pancreas. Matrix metalloproteinase-7 (MMP-7) is a secreted matrilysin, which contributes to angiogenesis and breakdown of basement membranes of pancreatic tissues. The present study was aimed to investigate the association of MMP-7 −181A/G (rs11568818) gene promoter polymorphism in patients with chronic pancreatitis. Methods: A total of 100 chronic pancreatitis patients and 150 unrelated healthy individuals were included in this case control study. The genotyping of the MMP-7 gene (− 181 A/G) (rs11568818) was carried out based on PCR-RFLP. The serum levels of MMP-7 were determined by ELISA. Association between genotypes and chronic pancreatitis was examined by odds ratio (OR) with 95% confidence interval (CI). Results: The frequencies of the genotypes in promoter of MMP-7 were AA 49 per cent, AG 25 per cent and GG 26 per cent in chronic pancreatitis patients and AA 53 per cent, AG 38 per cent and GG 9 per cent in control subjects. Frequency of MMP-7 −181GG genotype and − 181G allele was significantly associated with chronic pancreatitis compared to healthy subjects [OR = 1.58 (95% CI: 1.06 -2.36), p =0.019]. There was no significant difference in the serum MMP-7 levels in the patients compared to control subjects. Interpretation &conclusions: The present study revealed a significant association of MMP-7 -181A/G (rs11568818) GG genotype with chronic pancreatitis patients, indicating its possible association with the disease.

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