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Year : 2014  |  Volume : 140  |  Issue : 1  |  Page : 154-155

Hepatitis C in renal disease, hemodialysis and transplantation

Department of Nephrology All India Institute of Medical Sciences New Delhi 110 029, India

Date of Web Publication4-Sep-2014

Correspondence Address:
S K Agarwal
Department of Nephrology All India Institute of Medical Sciences New Delhi 110 029
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Source of Support: None, Conflict of Interest: None

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How to cite this article:
Agarwal S K. Hepatitis C in renal disease, hemodialysis and transplantation. Indian J Med Res 2014;140:154-5

How to cite this URL:
Agarwal S K. Hepatitis C in renal disease, hemodialysis and transplantation. Indian J Med Res [serial online] 2014 [cited 2021 Jun 13];140:154-5. Available from:

J.M. Morales, editor; B. Dominguez-Gil, J. M. Campistol, M. Jadoul, L. Rostaing, D.

Roth, co-editors (Karger, Basel, Switzerland) 2012.

134 pages. Price: US$ 233.00/CHF 198.00/EUR 165.00

ISBN 978-3-8055-9820-0

Hepatitis C virus (HCV) infection, unknown a few decades ago, is now the most common viral infection associated with the care of patients with renal diseases, both as a cause as well as a complication of renal disease. According to the World Health Organization (WHO), this urgent public health problem kills 3,50,000 people per year, and around 150 million have the chronic form of the hepatitis C infection in general population. Magnitude estimates are not well reported in patients with renal disease and the natural history of HCV in patients with chronic kidney disease (CKD) remains incompletely appreciated. Despite the introduction of protective measures in dialysis units and universal screening of blood products, HCV infection remains prevalent in patients on dialysis and kidney transplant recipients.

According to the DOPPS (Dialysis Outcomes and Practice Patterns Study) survey, which included nearly 80,000 patients on maintenance dialysis from the industrialized world, the mean prevalence of anti-HCV positive patients was reported to be 13.5 per cent. The prevalence in many developing nations is well above this figure and is under-reported. In India, some of the dialysis units have more than 50 per cent of the patients acquiring HCV infection after a few months of hemodialysis. Though many health care workers have already accepted poor long-term survival of patients with chronic kidney disease on dialysis, HCV infection has not been given due importance in hemodialysis setting by many of such health care providers.

The book has appropriate chapters starting from HCV magnitude, epidemiology and treatment in non-kidney disease patients to the controversial issues like handling immunosuppression and HCV treatment of patients following renal transplantation. As required, the major issue of HCV in dialysis population has been devoted nearly 40 per cent of the chapters as this is the crucial issue in renal disease patients. Currently all post-transplant patients are actually the continuum of patients during dialysis. Though not a major issue, a brief chapter on HCV during continuous ambulatory peritoneal dialysis (CAPD) was expected. Also, the absence of the most controversial issue of "isolation" of infected patients during hemodialysis was a disappointment. The issue is so controversial that it is always discussed in a large number of publications on HCV in dialysis, more so from the developing countries. Also, though not in applicability stage, the status of HCV vaccine should have also been discussed.

The chapters are short and the flow of content is reasonably good for the readers to cover a large number of pages in a short time. Tables and Figures are appropriately chosen to explain the issues. However, inclusion of coloured pictures would have made the book more attractive. Furthermore, though the chapters are well referenced, particularly in terms of including the latest references, there is a paucity of references from developing countries, which represent the opposite point of view in some of the related issues.

The book will be very useful for the physicians and nephrologists in developing countries to have a concise review on all the issues related to HCV and renal disease in the world. They can also take advantage of the chapters for planning their approach to patients with HCV infection in relation to maintenance dialysis and renal transplant programme.


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