Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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Year : 2014  |  Volume : 139  |  Issue : 6  |  Page : 822-834

Obesity-related inflammation & cardiovascular disease: Efficacy of a yoga-based lifestyle intervention

Department of Physiology, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Raj Kumar Yadav
Additional Professor, Department of Physiology, All India Institute of Medical Sciences New Delhi 110 029
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Source of Support: None, Conflict of Interest: None

PMID: 25109716

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Obesity is a global health burden and its prevalence is increasing substantially due to changing lifestyle. Chronic adiposity is associated with metabolic imbalance leading to dyslipidaemia, diabetes, hypertension and cardiovascular diseases (CVD). Adipose tissue acts as an endocrine organ releasing several adipocytokines, and is associated with increased levels of tissue and circulating inflammatory biomolecules causing vascular inflammation and atherogenesis. Further, inflammation is also associated independently with obesity as well as CVD. Keeping this in view, it is possible that a reduction in weight may lead to a decrease in inflammation, resulting in CVD risk reduction, and better management of patients with CVD. Lifestyle intervention has been endorsed by several health authorities in prevention and management of chronic diseases. A yoga-based lifestyle intervention appears to be a promising option in reducing the risk for CVD as well as management of patients with CVD as it is simple to follow and cost-effective with high compliance. The efficacy of such lifestyle intervention programmes is multifaceted, and is achieved via reduction in weight, obesity-related inflammation and stress, thereby culminating into risk reduction towards several chronic diseases including CVD. In this review, the association between obesity-related inflammation and CVD, and the role of yoga-based lifestyle intervention in prevention and management of CVD are discussed.

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