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Year : 2013  |  Volume : 138  |  Issue : 5  |  Page : 711-716

Inflammation & autoimmunity in human ageing: Dendritic cells take a center stage


Laboratories in Cellular & Molecular Immunology, Division of Basic & Clinical Immunology, University of California, Irvine, California, USA

Correspondence Address:
Sudhir Gupta
Professor of Medicine, Pathology & Laboratory Medicine, and Microbiology & Molecular Genetics, Chief, Basic and Clinical Immunology, Medical Sciences I, C-240, University of California at Irvine, Irvine, CA 92697
USA
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Source of Support: None, Conflict of Interest: None


PMID: 24434323

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Dendritic cells (DCs) play an important role in both immunological tolerance and immunity as well as in pro- and anti-inflammatory responses. Upon uptake of apoptotic cells and apoptotic bodies, DCs degrade self antigens from them and induce anti-inflammatory response and T regulatory (Treg) cells resulting in the maintenance of tolerance to self antigens. Ageing is characterized by progressive immunodeficiency, inflammation, and autoimmunity. In this paper we will review the role of DCs in inflammation and autoimmunity in human ageing and will highlight the observations that DCs from aged humans display impairment in their capacity to uptake apoptotic cells, and paradoxically induce proinflammatory response and increased reactivity to self antigen (DNA). DNA from aged is hypomethylated and hypomethylation is associated with increased immunogenecity of self DNA.


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