Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
  Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login  
  Home Print this page Email this page Small font sizeDefault font sizeIncrease font size Users Online: 361       
REVIEW ARTICLE
Year : 2013  |  Volume : 138  |  Issue : 5  |  Page : 620-631

T cell recognition of non-peptidic antigens in infectious diseases


1 SIgN (Singapore Immunology Network), A*STAR (Agency for Science, Technology & Research), Singapore
2 SIgN (Singapore Immunology Network), A*STAR (Agency for Science, Technology & Research), Singapore; Experimental Immunology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland

Correspondence Address:
Gennaro De Libero
Singapore Immunology Network (SigN), 8A Biomedical Grove, #04-06 Immunos, Singapore 138648

Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 24434317

Rights and PermissionsRights and Permissions

The immune system has evolved to recognize a wide range of antigenic molecules of self and non-self origin. The stimulatory antigens form complexes with antigen-presenting molecules and directly interact with the T cell receptor (TCR). Peptidic antigens associate with major histocompatibility complex (MHC) molecules and therefore, are indicated as MHC-restricted. Non-peptidic antigens do not bind to MHC molecules and are presented by other classes of antigen-presenting molecules. These non-MHC restricted antigens include glycolipid molecules, phosphorylated metabolites of the mevalonate pathway and vitamin B2 precursors. T cells specific for non-peptidic antigens have important roles in host defense against infections, autoimmunity, allergies and tumour immunosurveillance. Hence, understanding the molecular interactions between the antigen presenting cell (APC) and the T cells with non-peptidic specificity is of great relevance. Here, we review current knowledge of this type of T cells, their TCR repertoire, the structural aspects of recognized antigens, the mode of antigen recognition, and their function with special emphasis on their role in infectious diseases.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1202    
    Printed14    
    Emailed0    
    PDF Downloaded326    
    Comments [Add]    

Recommend this journal