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REVIEW ARTICLE
Year : 2013  |  Volume : 138  |  Issue : 5  |  Page : 595-608

T cell ageing: Effects of age on development, survival & function


1 National Institute of Immunology, New Delhi, India
2 Department of Biological Sciences, University of Arkansas, Fayetteville, Arkansas, USA

Correspondence Address:
Nasir Salam
National Institute of Immunology, Aruna Asaf Ali Road, New Delhi 110 067
India
Vineeta Bal
National Institute of Immunology, Aruna Asaf Ali Road, New Delhi 110 067
India
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Source of Support: None, Conflict of Interest: None


PMID: 24434315

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Age associated decline of the immune system continues to be a major health concern. All components of innate and adaptive immunity are adversely affected to lesser or greater extent by ageing resulting in an overall decline of immunocompetence. As a result in the aged population, there is increased susceptibility to infection, poor responses to vaccination, and increased incidence of autoreactivity. There is an increasing focus on the role of T cells during ageing because of their impact on the overall immune responses. A steady decline in the production of fresh naïve T cells, more restricted T cell receptor (TCR) repertoire and weak activation of T cells are some of the effects of ageing. In this review we summarize our present understanding of the effects of ageing on naïve CD4 T cells and potential approaches for therapeutic interventions to restore protective immunity in the aged population.


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