Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
  Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login  
  Home Print this page Email this page Small font sizeDefault font sizeIncrease font size Users Online: 2651       
REVIEW ARTICLE
Year : 2013  |  Volume : 137  |  Issue : 4  |  Page : 680-694

MicroRNA in carcinogenesis & cancer diagnostics: A new paradigm


1 Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia
2 School of Biological Sciences, Indian Institute of Technology, Delhi, New Delhi, India
3 King Abdullah Institute for Nanotechnology, King Saud University, Riyadh, Saudi Arabia
4 Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia; Department of Microbiology, Faculty of Agricultural Sciences, AMU, Aligarh, India

Correspondence Address:
Seyed E Hasnain
School of Biological Sciences, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi 110 016
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 23703335

Rights and PermissionsRights and Permissions

MicroRNAs (miRNAs) are small 22-25 nucleotides long non-coding RNAs, that are conserved during evolution, and control gene expression in metazoan animals, plants, viruses, and bacteria primarily at post-transcriptional and transcriptional levels. MiRNAs ultimately regulate target gene expression by degrading the corresponding mRNA and/or inhibiting their translation. Currently, the critical functions of miRNAs have been established in regulating immune system, cell proliferation, differentiation and development, cancer and cell cycle by as yet unknown control mechanism. MiRNAs play an essential role in malignancy, and as tumour suppressors and oncogenes. Thus, discovery of new miRNAs will probably change the landscape of cancer genetics. Significantly different miRNA profiles can be assigned to various types of tumours, which could serve as phenotypic signatures for different cancers for their exploitation in cancer diagnostics, prognostics and therapeutics. If miRNA profiles can accurately predict malignancies, this technology could be exploited as a tool to surmount the diagnostic challenges. This review provides comprehensive and systematic information on miRNA biogenesis and their implications in human health.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2654    
    Printed36    
    Emailed0    
    PDF Downloaded836    
    Comments [Add]    

Recommend this journal