Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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CENTENARY REVIEW ARTICLE
Year : 2012  |  Volume : 136  |  Issue : 5  |  Page : 729-738

Tropical endomyocardial fibrosis in India: A vanishing disease!


1 Kerala Institute of Medical Sciences, Medical College, Thiruvananthapuram, India
2 Sree Chitra Tirunal Institute for Medical Sciences & Technology, Medical College, Thiruvananthapuram, India

Correspondence Address:
G Vijayaraghavan
Vice Chairman & Director Medical Services, Kerala Institute of Medical Sciences, PB No. 1, Anayara P.O., Thiruvananthapuram 695 029
India
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Source of Support: None, Conflict of Interest: None


PMID: 23287119

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Tropical endomyocardial fibrosis in India was a common medical problem in the coastal districts of south India, especially the Kerala State. The clinical and autopsy studies have shown left and right ventricular apical fibrosis, with varying degree of atrioventricular valve regurgitation. Left ventricular endomyocardial fibrosis presents with severe pulmonary hypertension and right ventricular endomyocardial fibrosis presents very high systemic venous pressure and congestive cardiac failure. Surgical management improved the natural history of the disease to some extent. Various infectious and toxic factors were postulated regarding its aetiology. During the last few years, incidence of the disease has decreased considerably. The only explanation identified is the significant improvement in the living standards of the people with the corresponding decline in the childhood malnutrition, infections, worm infestation and associated eosinophilia.


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