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Year : 2012  |  Volume : 135  |  Issue : 4  |  Page : 568

Gene therapy for autoimmune and inflammatory diseases

Vivekananda Polyclinic & Institute of Medical Sciences, Lucknow 226 007, India

Date of Web Publication29-May-2012

Correspondence Address:
S S Agarwal
Vivekananda Polyclinic & Institute of Medical Sciences, Lucknow 226 007
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Source of Support: None, Conflict of Interest: None

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How to cite this article:
Agarwal S S. Gene therapy for autoimmune and inflammatory diseases. Indian J Med Res 2012;135:568

How to cite this URL:
Agarwal S S. Gene therapy for autoimmune and inflammatory diseases. Indian J Med Res [serial online] 2012 [cited 2021 May 19];135:568. Available from:

Gene therapy for autoimmune and inflammatory diseases, Y. Chernajovsky, P.D. Robbins, editors (Springer, Basel, Switzerland) 2010. 239 pages. Price: not mentioned

ISBN 978-3-0346-0164-1

It is a multi-authored monograph under the series titled Milestones in Drug Therapy. There are 15 chapters in the monograph, first nine deal with specific diseases viz., Gene therapy for rheumatoid arthritis, Inflammatory bowel disease, Diabetes (type 1), Cystic fibrosis, Multiple sclerosis, Myositis, Osteoarthritis, Sjogren's syndrome and Lupus. The next five chapters deal with more technical aspects of gene therapy viz., Regulated promoters, Development of AAV vectors, Delivery and application of plasmid DNA, Helper-dependent Adenoviral vectors and Cells as carriers of gene therapy. The last chapter is written by the editors themselves and is titled 'Perspectives for the future developments of gene therapy for autoimmune and inflammatory therapy'.

The title of the book itself and the contents clearly show that the scope of genetic manipulation (which includes all forms of gene therapy) is very wide. In fact, the very first application of gene therapy, as well as the latest most successful one, have been for Severe Combined Immunodeficiency Disorder, albeit genetic one. Also, several gene therapy trials in cancer have been focused on modulation of immune response. The advantages of delivery of effecter molecules through genes include avoidance of systemic effects, and hopefully a sustained and regulated response at the site of interest. More importantly the best proof for pathophysiological role of a gene in causation of the disease or its manifestations is the therapeutic gain that can be achieved by its manipulation. The monograph greatly succeeds in exploring this relationship.

Each chapter is written by an international authority in the field who is well versed with the subject. In introduction to each chapter there is sufficient information about the disease including its pathophysiology, clinical manifestations and standard therapy that brings out current knowledge and its limitations. Being part of the Milestones in Drug Therapy series, the focus of each chapter is on emerging therapies - particularly the gene therapy. It identifies the gene targets, approaches for gene therapy and advances made in their translation in the experimental systems. There is considerable information on gene constructs, vector designs and delivery systems in general and those used for each disease entity reviewed in the book. It also provides up-to-date information about various clinical trials wherever these have been undertaken. Overall, the information is quite extensive and useful. Each chapter is well referenced.

This monograph is highly specialized but is easily understandable. It is recommended for all researchers - both clinical and non-clinical, particularly those working in the fields of gene therapy, immunology, rheumatology, pharmacology and molecular medicine. It will also be a useful reference source for the libraries of all advanced academic centers and research institutions.


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