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Year : 2012  |  Volume : 135  |  Issue : 4  |  Page : 565-566

Prehypertension associated with dyslipidaemia in young adults - Life-style & telomeres

Department of Physiology, Mahatma Gandhi Mission's Medical College, Kamothe, Navi Mumbai 410 209, India

Date of Web Publication29-May-2012

Correspondence Address:
Mahantayya V Math
Department of Physiology, Mahatma Gandhi Mission's Medical College, Kamothe, Navi Mumbai 410 209
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Source of Support: None, Conflict of Interest: None

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How to cite this article:
Math MV. Prehypertension associated with dyslipidaemia in young adults - Life-style & telomeres. Indian J Med Res 2012;135:565-6

How to cite this URL:
Math MV. Prehypertension associated with dyslipidaemia in young adults - Life-style & telomeres. Indian J Med Res [serial online] 2012 [cited 2021 May 19];135:565-6. Available from:


I read the article by Ray and colleagues [1] on the prevalence of prehypertension associated with dyslipidaemia and overweight in young military adults and also the commentary by Pappachan [2] . The high prevalence of prehypertension (79.8%) associated with a decrease in HDL cholesterol (67%) in young military adults in this study shows the need for intervention in their life-style as also noted by the authors [1],[2] . It would be nice to know the quantity of salt and ghee/ butter intake per day by the subjects in the study [1] . Though majority of Indians eat home cooked food, there is an increasing trend to consume more often commercially prepared deep fried foods and carbonated soft drinks. Per capita consumption of fruits and vegetables in our country is low [3] . The longer duration of cooking in homes and restaurants can also result in destruction of antioxidants in food. In our country, there is high incidence of dental and periodontal disease in adolescents and in adults [4] . A positive association between periodontal disease and cardiovascular disease has been shown [5],[6] . Desvarieux et al[7] have shown a direct relationship between the levels of subgingival periodontal bacteria and both systolic and diastolic blood pressure as well as hypertension [7] .

Telomere dysfunction is an important factor in the pathogenesis of hypertension and atherosclerosis [8] . Telomere length is related to ageing and is inversely associated with risk of cardiovascular disease [8],[9],[10] . Telomere length is regulated by genetic and environmental factors [8] . Hypertension, diabetes mellitus, increased insulin resistance and oxidative stress are associated with shorter telomere length [9],[10] . Ornish and colleagues [11] have observed that with intensive changes in lifestyle over a period of three months there was significant increase in telomerase activity, and decrease in low-density lipoprotein (LDL) cholesterol and psychological distress. A decrease in duration of sleep over many nights has been observed to increase blood pressure through increased salt retention [12] . Ignorance, underdiagnosis and suboptimal control are important factors for increased prevalence of hypertension in South Asia [13] . Adults who sleep less than five hours each night have an increased risk of developing hypertension [14],[15] . As suggested by Pappachan [2] , there is a need for urgent action to prevent lifestyle diseases in India.

   References Top

1.Ray S, Kulkarni B, Sreenivas A. Prevalence of prehypertension in young military adults & its association with overweight & dyslipidaemia. Indian J Med Res 2011; 134 : 162-7.  Back to cited text no. 1
2.Pappachan MJ. Increasing prevalence of lifestyle diseases: high time for action. Indian J Med Res 2011; 134 : 143-5.  Back to cited text no. 2
3.Codaty J. Dr. Colluthur Gopalan changing the way people eat. House Calls 2004; 6 : 66-71.   Back to cited text no. 3
4.First National Oral Health Survey. Colgate-Palmolive (India) Limited, Mumbai. September 29, 2004. Available from:, accessed on September 29, 2004.  Back to cited text no. 4
5.Desvarieux M, Demmer RT, Rundek T, Boden-Albala B, Jacobs DR Jr, Sacco RL, et al. Periodontal microbiota and carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology Study (INVEST). Circulation 2005; 111 : 576-82.  Back to cited text no. 5
6.Demmer RT, Desvarieux M. Periodontal infections and cardiovascular disease: the heart of the matter. J Am Dent Assoc 2006; 137 (Suppl): 14S-20S.   Back to cited text no. 6
7.Desvarieux M, Demmer RT, Jacobs DR Jr, Rundek T, Boden-Albala B, Sacco RL, et al. Periodontal bacteria and hypertension: the Oral Infections and Vascular Disease Epidemiology Study (INVEST). J Hypertens 2010; 28 : 1413-21.  Back to cited text no. 7
8.Serrano AL, Andrés V. Telomeres and cardiovascular disease: Does size matter? Circ Res 2004; 94 : 575-84.   Back to cited text no. 8
9.Demissie S, Levy D, Benjamin EJ, Cupples LA, Gardner JP, Herbert A, et al. Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell 2006; 5 : 325-30.  Back to cited text no. 9
10.Nilsson PM. Telomeres and cardiovascular disease: new perspectives in hypertension. J Hum Hypertens 2011; 25 : 703-4.  Back to cited text no. 10
11.Ornish D, Lin J, Daubenmier J, Weidner G, Epel E, Kemp C, et al. Increased telomerase activity and comprehensive lifestyle changes: a pilot study. Lancet Oncol 2008; 9 : 1048-57.  Back to cited text no. 11
12.Gangwisch JE. Epidemiological evidence for the links between sleep, circadian rhythms and metabolism. Obes Rev 2009; 10 (Suppl 2): 37-45.  Back to cited text no. 12
13.Sharma S. Hypertension and cardiovascular disease in South Asia: No end in sight. J Am Soc Hypertens 2008; 2 : 125-30.  Back to cited text no. 13
14.Gangwisch JE, Heymsfield SB, Boden-Albala B, Buijs RM, Kreier F, Pickering TG, et al. Short sleep duration as a risk factor for hypertension: analyses of the First National Health and Nutrition Examination Survey. Hypertension 2006; 47 : 833-9.  Back to cited text no. 14
15.Williams B. The year in hypertension. J Am Coll Cardiol 2008; 51 : 1803-17.  Back to cited text no. 15


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