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REVIEW ARTICLE
Year : 2012  |  Volume : 135  |  Issue : 4  |  Page : 479-484

A pragmatic & translational approach of human biomonitoring to methyl isocyanate exposure in Bhopal


Division of Translational Research, Tata Memorial Centre, ACTREC, Navi Mumbai, India

Correspondence Address:
Pradyumna Kumar Mishra
Scientific Officer-E, Division of Translational Research, Tata Memorial Centre, ACTREC, Navi Mumbai 410 210
India
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Source of Support: None, Conflict of Interest: None


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Human biomonitoring has evolved beyond margins to ascertain exposure-response relationship in environmental associated human diseases. As occupational ailments continue to dominate global concerns, biomonitoring strategies have evolved better in terms of evaluating health risks associated with systemic uptake from chronic (long-term) environment exposures. Even though contributions of acute toxic exposures (short-term) towards initiation of disease processes have been gradually recognized, a comprehensive approach delineating mechanistic insights of such an implication remains elusive. Molecular biomonitoring in a strictly selected defined surviving cohort of the infamous Bhopal gas tragedy "as a model", could provide an unparallel opportunity to discern the long standing implications of acute exposures. Besides comprehending clinical significance of isocyanate toxicity, the results might provide a framework for understanding the molecular repercussions pertaining to a host of other such acute environmental exposures. The investigative strategy might also be helpful in identification of biomarkers with potential for translational research.


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