Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
  Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login  
  Home Print this page Email this page Small font sizeDefault font sizeIncrease font size Users Online: 3363       

   Table of Contents      
CORRESPONDENCE
Year : 2011  |  Volume : 133  |  Issue : 4  |  Page : 446-447

New metallo-β-lactamase: Is its name after New Delhi helpful or harmful?


Rollins School of Public Health at Emory University, 1518 Clifton Road Atlanta, Georgia 30322, USA

Date of Web Publication29-Apr-2011

Correspondence Address:
T J John
439 Civil Supplies Godown Lane, Kamalakshipuram, Vellore, TN, 632 002, India

Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 21537101

Rights and PermissionsRights and Permissions

How to cite this article:
Jain M, John T J. New metallo-β-lactamase: Is its name after New Delhi helpful or harmful?. Indian J Med Res 2011;133:446-7

How to cite this URL:
Jain M, John T J. New metallo-β-lactamase: Is its name after New Delhi helpful or harmful?. Indian J Med Res [serial online] 2011 [cited 2021 Mar 2];133:446-7. Available from: https://www.ijmr.org.in/text.asp?2011/133/4/446/80139

Sir,

We read with great interest the editorial on the new metallo-β-lactamase[1] . It gives a clear picture of β-lactamases in general and the new one named NDM-1 in particular. It is also an alert on "the disorganized state of antibiotic therapy in India"[1] . While addressing the lack of evidence for New Delhi as the place of origin of the plasmid encoding the enzyme, the author states that "our national sentiments are tickled" and that its naming (after New Delhi) "is not really objectionable but questionable" [1] .

While several metallo-β-lactamases have been named after cities where they originated or were detected first without deleterious effects, the naming of the new one with our nation's capital has had much negative impact [2],[3] . It was not detected in New Delhi, and there is insufficient evidence of its place of origin [1],[2] . The name was misused in one paper to warn people to avoid India as a destination for surgical treatment as if the problem was predominantly and almost exclusively in India [4] . The editor of that journal has even tendered a public apology for publishing it [5]. The plasmid in question is globally widespread as are many others carrying other β-lactamases[6] . There is a public appeal on the electronic web, requesting the removal of New Delhi from the name, already signed by over 5000 individuals [3] .

The objection to naming the plasmid after India's capital actually arose after its misuse for discouraging medical tourism in India which is an economically growing enterprise [7] . Thus, its naming has become objectionable in addition to being questionable. We propose that the name be changed, although such a step is unprecedented. However, there are already over 30 β-lactamases carrying alternate names[8] . We also propose that hereafter names of places or persons be avoided for newly discovered biological agents.

Has the name helped in increasing public perception of the "disorganized state of antibiotic therapy" in India? The answer is no, but on the other hand the media and even government officials went into a defensive mode, thus missing a good opportunity to publicly discuss the need for organization and discipline of antibiotic availability, choice and clinical use so as to reduce the spread of existing antibiotic-resistant microbes and to prevent others from developing. We know that D. Ragunath is a leader in the area of antimicrobial resistance. We urge him, the Indian Council for Medical Research, the Departments of Health Research and Health & Family w0 elfare and other concerned agencies to take the combat against antibiotic misuse on a 'war footing' with enforceable regulations and legislations.

 
   References Top

1.Ragunath D. New metallo-β lactamase NDM-1. Indian J Med Res 2010; 132 : 478-81.  Back to cited text no. 1
    
2.Yong D, Toleman MA, Giske CG, Cho HS, Sundman K, Lee K, et al. Characterization of a new metallo-beta-lactamase gene, bla (NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother 2009; 53 : 5046-54.  Back to cited text no. 2
    
3. http://www.changesuperbugname.com , accessed on February 21, 2011.  Back to cited text no. 3
    
4.Kumarasamy KK, Toleman MA, Walsh TR, Bagaria J, Butt F, Balakrishnan R, et al. Emergence of a new antibiotic reistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis 2010; 20 : 597-602.  Back to cited text no. 4
    
5.Kounteya S. Lancet says sorry for ′Delhi bug′. Available from: http://timesofindia.indiatimes.com/india/Lancet-says-sorry-for-Delhi-bug-/articleshow/7261135.cms , accessed on February 22, 2011.  Back to cited text no. 5
    
6.Koh TH, Khoo CT, Wijaya L, Leong HN, Lo YL, Lim LC, et al. Global spread of New Delhi metallo-beta-lactamase-1. Lancet Infect Dis 2010; 10 : 828.   Back to cited text no. 6
    
7.Shetty P. Medical tourism booms in India, but at what cost? Lancet 2010; 376 : 671.  Back to cited text no. 7
    
8.Jacoby G. Mini review. Beta lactamase nomenclature. Antimicrob Agents Chemother 2006; 50 : 1123-9.  Back to cited text no. 8
    




 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    References

 Article Access Statistics
    Viewed874    
    Printed50    
    Emailed0    
    PDF Downloaded201    
    Comments [Add]    

Recommend this journal