Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
  Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login  
  Home Print this page Email this page Small font sizeDefault font sizeIncrease font size Users Online: 2587       
REVIEW ARTICLE
Year : 2011  |  Volume : 133  |  Issue : 2  |  Page : 212-217

Genetic components of stringent response in Vibrio cholerae


Infectious Diseases & Immunology Division, Indian Institute of Chemical Biology (CSIR), Kolkata, India

Correspondence Address:
Rupak K Bhadra
Infectious Diseases & Immunology Division, Indian Institute of Chemical Biology (CSIR) 4 Raja S.C. Mullick Road, Jadavpur, Kolkata 700 032
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 21415497

Rights and PermissionsRights and Permissions

Nutritional stress elicits stringent response in bacteria involving modulation of expression of several genes. This is mainly triggered by the intracellular accumulation of two small molecules, namely, guanosine 3'-diphosphate 5'-triphosphate and guanosine 3',5'-bis(diphosphate), collectively called (p)ppGpp. Like in other Gram-negative bacteria, the cellular level of (p)ppGpp is maintained in Vibrio cholerae, the causative bacterial pathogen of the disease cholera, by the products of two genes relA and spoT. However, apart from relA and spoT, a novel gene relV has recently been identified in V. cholerae, the product of which has been shown to be involved in (p)ppGpp synthesis under glucose or fatty acid starvation in a ∆relAspoT mutant background. Furthermore, the GTP binding essential protein CgtA and a non-DNA binding transcription factor DksA also seem to play several important roles in modulating stringent response and regulation of other genes in this pathogen. The present review briefly discusses about the role of all these genes mainly in the management of stringent response in V. cholerae.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2455    
    Printed65    
    Emailed0    
    PDF Downloaded428    
    Comments [Add]    

Recommend this journal