Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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REVIEW ARTICLE
Year : 2009  |  Volume : 130  |  Issue : 3  |  Page : 222-233

Infection of human papillomaviruses in cancers of different human organ sites


1 Division of Molecular Oncology, Institute of Cytology & Preventive Oncology (ICMR), Noida, India
2 Dr B.R. Ambedkar Center for Biomedical Research, University of Delhi (North Campus), Delhi 110 007, India

Correspondence Address:
Bhudev C Das
Dr B.R. Ambedkar Center for Biomedical Research, University of Delhi (North Campus), Delhi 110 007, India

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Source of Support: None, Conflict of Interest: None


PMID: 19901431

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Clinico-epidemiological and molecular studies have established the casual link between Human Papillomavirus (HPV) infection and cervical cancer as also association of HPV infection with several other cancers. In India, cervical cancer is a leading cancer among women and almost all cases of cervical cancer show prevalence of High Risk (HR)-HPV infection. HPV has been also detected in a significant proportion of oral, esophageal, anal, vaginal, vulvar, and penile cancer and in a small percentage of lung, laryngeal, and stomach cancer in India. Due to lack of organized HPV screening program, insufficient infrastructure and trained manpower and inadequacy in cancer registries, there are not much data available on the countrywide HPV prevalence and its type distribution in different cancers in India. Forthcoming introduction of recently developed HPV vaccines in India given a new urgency to know the prevalence and distribution of various HPV types in different organ sites for the management and monitoring of vaccination program and its impact on prevalence of other cancers. This review, summarizes studies on the prevalence of HPV infection in cancers of different organ sites in India.


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