Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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REVIEW ARTICLE
Year : 2009  |  Volume : 130  |  Issue : 2  |  Page : 115-124

Helicobacter pylori vaccine : mucosal adjuvant & delivery systems


The First Affiliated Hospital of Nanchang University, Nanchang, China

Correspondence Address:
X Yong
The First Affiliated Hospital of Nanchang University, Nanchang, China

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Source of Support: None, Conflict of Interest: None


PMID: 19797807

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Vaccination, especially mucosal vaccination, is considered to be effective in the management of Helicobacter pylori infections. However, most antigens alone cannot induce immune responses when administered mucosally and need to be co-administered with adjuvants or delivery systems. The current research on the mucosal adjuvant and delivery systems of vaccine against H. pylori, including advantages and disadvantages, mechanisms and applications is discussed in this review. Mutants of cholera toxin (CT) and the heat labile enterotoxin of Escherichia coli (LT), CpG oligodeoxynucleotides, biocompatible and biodegradable polymers, and live attenuated bacterial vectors may be promising adjuvant and delivery systems for H. pylori vaccine.


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