Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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ORIGINAL ARTICLE
Year : 2009  |  Volume : 129  |  Issue : 1  |  Page : 59-63

Establishment of T-lymphocyte subset reference intervals in a healthy adult population in Chennai, India


1 YRG Centre for AIDS Research & Education, Voluntary Health Services Hospital Campus Rajiv Gandhi Salai, Chennai India
2 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, USA
3 Brown University/Miriam Hospital, Providence, USA

Correspondence Address:
K G Murugavel
YRG Centre for AIDS Research & Education, Voluntary Health Services Hospital Campus Rajiv Gandhi Salai, Chennai India

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Source of Support: None, Conflict of Interest: None


PMID: 19287058

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Estimation of CD4+ T-lymphocytes continues to be an important aspect for monitoring HIV disease progression and response to antiretroviral therapy. Most of the diagnostic laboratories often rely on western text books for CD4+ T-lymphocyte reference values, which could, often be unreliable for usage in local settings. Therefore, we attempted to establish the reference values for T-lymphocyte subsets among healthy adults in a cross-sectional study carried out at the YRG Centre for AIDS Research and Education (YRG CARE) in Chennai, south India, in 213 (84 female and 129 male) healthy, HIV-1/2 seronegative adults as volunteers. Whole blood specimens were processed for CD4+, CD8+ T-lymphocyte estimation and haematological parameters. The established range of CD4+ T-lymphocyte counts for men and women were 383-1347 cells/microl (mean 865 and median 845 cells/microl) and 448-1593 cells/microl (mean 1021 and median 954 cells/microl), respectively. Women had significantly higher absolute CD4+ Tlymphocyte counts (P<0.001) and CD4+:CD8+ T-lymphocyte ratio as compared to men. The established normal range of CD4+ T-lymphocyte % was 21-59 (mean 40.2 and median 40.1). The influence of age was not observed in any of the parameters except CD4+/CD8+ T-lymphocyte ratio with the >45 yr age group. Further studies with greater sample size may be required to define the staging of HIV disease in relation to the normal CD4 T-lymphocyte count in the general population.


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