Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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REVIEW ARTICLE
Year : 2009  |  Volume : 129  |  Issue : 1  |  Page : 11-18

Animal models of tuberculosis for vaccine development


1 Experimental Animal Facility, National JALMA Institute for Leprosy & Other Mycobacterial Diseases, Agra, India
2 Secretary, Department of Health Research, Government of India & Director-General, Indian Council of Medical Research, V. Ramalingaswami Bhawan, Ansari Nagar, New Delhi 110 029, India

Correspondence Address:
U D Gupta
Experimental Animal Facility, National JALMA Institute for Leprosy & Other Mycobacterial Diseases, Agra, India

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Source of Support: None, Conflict of Interest: None


PMID: 19287053

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Animal models for testing different vaccine candidates have been developed since a long time for studying tuberculosis. Mice, guinea pigs and rabbits are animals most frequently used. Each model has its own merits for studying human tuberculosis, and none completely mimics the human disease. Different animal models are being used depending upon the availability of the space, trained manpower as well as other resources. Efforts should continue to develop a vaccine which can replace/outperform the presently available vaccine BCG.


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