Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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REVIEW ARTICLE
Year : 2008  |  Volume : 128  |  Issue : 4  |  Page : 448-461

Copper & biological health


1 Department of Biosciences, Sri Sathya Sai University, Prasanthi Nilayam, India
2 Michigan Center for Translational Pathology & Department of Pathology, University of Michigan, Ann Arbor, MI, USA
3 Center for Molecular Medicine, Department of Molecular Medicine & Surgery, Karolinska Hospital, Stockholm, Sweden

Correspondence Address:
S Krupanidhi
Department of Biosciences, Sri Sathya Sai University, Prasanthi Nilayam, India

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Source of Support: None, Conflict of Interest: None


PMID: 19106440

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Cu being a transition metal is ubiquitously engaged in biological systems to derive electrons through its participation in several enzymatic reactions. Upon bestowing the significance of Cu in biological systems, an elaborate mechanism is set forth by nature for maintaining Cu homeostasis. As a consequence, a wide variety of proteins viz., family of Cu bearing proteins, cuproenzymes, Cu transporters and Cu chaperone proteins have been manifested for enabling Cu to show its relevance in biological health. In addition, understanding the role of Cu in hepatic and neuronal functions and also in angiogenesis keeps progressing with the advent of novel molecular tools. The studies on genetic defects in Cu metabolism causing abnormalities are providing insights leading to the possible prognostic cues to alleviate the sufferings.


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