Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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REVIEW ARTICLE
Year : 2006  |  Volume : 124  |  Issue : 6  |  Page : 613-618

Autologous transplantation in the central nervous system


National Neuroscience Institute, National University of Singapore & Nanyang Technological University, Singapore

Correspondence Address:
P Taupin
National Neuroscience Institute, National University of Singapore & Nanyang Technological University, Singapore

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Source of Support: None, Conflict of Interest: None


PMID: 17287548

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Cell transplantation has been proposed to replace lost neurons in the diseased brain, and after injuries to the central nervous system (CNS). Strategies for cellular therapy in the CNS consist primarily in heterologous transplantations. Despite the CNS being an immunologically privileged site, immune rejection of intracerebral transplants remains a concern. In addition, the use of immunosuppressive drugs, like cyclosporine, is a major constraint associated with heterologous transplantations. Autologous transplantation is therefore viewed as the model of choice for cellular therapy. With the recent progress in somatic cell nuclear transfer (SCNT) research, and the confirmation that neurogenesis occurs in the adult brain and neural stem cells (NSCs) reside in the adult CNS, new opportunities for autologous transplantations are being considered for the CNS, and are promising.


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