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  Indian J Med Microbiol
 

Figure 2: Interconnected responsible pathways to cause amyloid and tau accumulation. Gene involved in AD pathogenesis can be broadly grouped into 3 categories; immune response (CR1, MS4A, TREM2, CD33, EPHA1), cholesterol metabolism (APOE, CLU, ABCA7), synaptic function (PICALM, CD2AP, BIN1). The cumulative effect of all these genes is manifested through the final common pathway of amyloid and tau cascade.

Figure 2: Interconnected responsible pathways to cause amyloid and tau accumulation. Gene involved in AD pathogenesis can be broadly grouped into 3 categories; immune response (CR1, MS4A, TREM2, CD33, EPHA1), cholesterol metabolism (APOE, CLU, ABCA7), synaptic function (PICALM, CD2AP, BIN1). The cumulative effect of all these genes is manifested through the final common pathway of amyloid and tau cascade.