Figure 5. SMAR1 downregulated in human patients suffering from systemic inflammatory disorders. CD4+ T cells were isolated from the synovial fluid of the control normal individuals (1) and rheumatoid arthritis patients (2) and the transcript levels of SMAR1 and IL-17 are quantitatively analyzed using real time PCR. Fifty samples each were analyzed and the result is the cumulative data of the same. Statistical significance was verified with unpaired students t test. **P <0.001 compared with healthy (1).