Figure. 1. Comparison of the colon architecture in SMAR1 transgenic (Tg.) and control mice of DSS induced colitis. (A) Colon size of control and SMAR1 Tg. mice after 10 days of DSS induced colitis are shown at the same scale. (B) Body weight loss of WT and SMAR1 Tg. mice treated with DSS and weighted every alternate day. Values are mean ± SEM (n=6). (C) Histological analysis using H & E staining of colon from untreated and DSS treated wild type (WT) and SMAR1 Tg. mice. Displayed images show colon cross-sections with similar region shown by arrows. Inset shows 10×magnification 10 days after colitis induction. (D) Colon length of DSS treated mice was measured 10 days after DSS treatment. Data represent the mean ± SEM of n=5 mice/genotype. P value were calculated with unpaired student's t test; *P<</i>0.005.