Figure 2(A): Expression of LDL receptor (LDLR) in HepG2 cells in the presence of different concentrations (0 to 1000 nM) of JAK2 inhibitor II. LDLR expression was detected by western blotting in presence of varying concentrations of JAK2 inhibitor II. Each bar in the graph represents mean ± SD (%IDV normalized against respective β-actin expression); n=3. (B) Expression of LDL receptor by HepG2 cells in the presence of various leptin concentrations with 0, 250, 500 and 1000 nM JAK2 inhibitor-ll. Using three concentrations (250, 500 and 1000 nM) of the JAK2 inhibitor II from Figure 2A, their effects on modulation of LDLR expression was detected by Western blotting.