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  Indian J Med Microbiol
 

Figure 2: Activation of latent HIV by antigens- Findings of the NARI study: Since the pool of HIV infected cells consists of HIV specific CD4 memory cells, it is possible to reativate HIV from these cells with HIV antigens. These cells also include HIV reservoirs which are essentially latently infected cells. HIV infected cells predominately secrete IL-10 upon reactivation, which can suppress immune cells required for elimination of HIV infected cells. Hence, IL-10 blockade is essential to eliminate these cells by activation.

Figure 2: Activation of latent HIV by antigens- Findings of the NARI study: Since the pool of HIV infected cells consists of HIV specific CD4 memory cells, it is possible to reativate HIV from these cells with HIV antigens. These cells also include HIV reservoirs which are essentially latently infected cells. HIV infected cells predominately secrete IL-10 upon reactivation, which can suppress immune cells required for elimination of HIV infected cells. Hence, IL-10 blockade is essential to eliminate these cells by activation.