Figure 1 (A): Effect of HgCl2 on plasma creatinine and blood urea nitrogen (BUN). Single dose of HgCl2 (7 mg/kg, bw) was administered in C57BL6/J mice. At each time interval, plasma creatinine and blood urea nitrogen level was estimated. The highest values were noticed on second day of the treatment. Number of mice (n) = 6 for each group, *P<0.01 compared to day 0 and day 1. (B) Effect of HgCl2 on histology of kidney. Normal saline and HgCl2 was administered in two groups of mice. At each time interval, mice were sacrificed and 5 μm tissue sections were stained with H&E. The pathological changes in the kidney tissue include interstitial oedema, tubular dilation, and sloughing of individual epithelial cells. Sloughing of brush borders with tubular dilation was clearly evidenced in straight proximal tubules of outer medulla outer strip. Intraluminal granular casts were frequently observed. Control section shows intact tubules and glomeruli. Arrows indicate granular casts. Magnification 200×.