Figure 5: Histopathological images. (A) Cut surface of spleen showing nodular lesions. (B) Microscopic examination from the lesions showing necrotizing granulomatous reaction with Langhans giant cells (arrows) on H&E stain; 400x. (C) These granulomas are rich in reticulin fibers as seen on silver stain; 200x. (D & E) Liver biopsy showing granulomatous reaction in the portal tract with Langhans giant cells and areas of necrosis (arrow in D and arrow head in E) on H&E stain at 100 & 200x respectively. (F) Arthroscopic synovial biopsy showing non-caseating granulomas (arrow) on H&E stain; 100x.