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  Indian J Med Microbiol
 

Figure 1: Immunohistochemical staining of MMR gene proteins, x 200 magnification. (A) Positive nucleus staining for MLH1 protein in normal colon (left) and absent staining in colon cancer (right). (B) Positive nucleus staining for PMS2 protein in normal colon (upper) and absent staining in colon cancer (lower). (C) Positive nucleus staining for MSH2 protein in normal colon (right) and colon cancer (left). (D) Absent nucleus staining for MSH2 protein in mucinous carcinoma (left) and positive staining in fibrous stromal cells, as internal control (right). (E) Scattered positive nucleus staining for MSH6 in colon cancer. (F) Absent nucleus staining and weak cytoplasm staining for MSH6 in colon cancer.

Figure 1: Immunohistochemical staining of MMR gene proteins, x 200 magnification. (A) Positive nucleus staining for MLH1 protein in normal colon (left) and absent staining in colon cancer (right). (B) Positive nucleus staining for PMS2 protein in normal colon (upper) and absent staining in colon cancer (lower). (C) Positive nucleus staining for MSH2 protein in normal colon (right) and colon cancer (left). (D) Absent nucleus staining for MSH2 protein in mucinous carcinoma (left) and positive staining in fibrous stromal cells, as internal control (right). (E) Scattered positive nucleus staining for MSH6 in colon cancer. (F) Absent nucleus staining and weak cytoplasm staining for MSH6 in colon cancer.