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   2008| June  | Volume 127 | Issue 6  
    Online since May 11, 2011

 
 
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ORIGINAL ARTICLES
Correlates of overweight & obesity among school going children of Wardha city, Central India
DR Bharati, PR Deshmukh, BS Garg
June 2008, 127(6):539-543
PMID:18765871
Full text not available  [PDF]  [PubMed]
  93 377 -
CORRESPONDENCES
Resurgence of diphtheria in Malegaon & Dhule regions of north Maharashtra
MN Dravid, SA Joshi
June 2008, 127(6):616-617
PMID:18765883
Full text not available  [PDF]  [PubMed]
  132 213 -
REVIEW ARTICLES
Preparedness for AIDS vaccine trials in India
JL Excler, S Kochhar, S Kapoor, S Das, J Bahri, Meenakshi Datta Ghosh, NK Ganguly, A Nayyar, M Chataway
June 2008, 127(6):531-538
PMID:18765870
India bears a heavy disease burden of HIV/AIDS infected and affected people. A safe, effective and accessible preventive AIDS vaccine, used along with other preventive interventions, is urgently needed to stem the epidemic. This review highlights the extensive preparedness activities undertaken from 2002 by the International AIDS Vaccine Initiative (IAVI), its Indian government and non government partners with the Indian scientific, political, media and community stakeholders and the capacity building process, before the conduct of the first ever AIDS vaccine trials in India in early 2005. Issues addressed included mistrust of clinical research due to past history of some unethical trials, transparency, community involvement, stigma and discrimination, provision for care and treatment of participants, informed consent, gender considerations, approval process, and operational aspects. The strong political support along with preparedness activities led to the successful conduct of AIDS vaccine trials enrolling equitably healthy women and men from all sections of society. This has paved the way for future vaccine trials in the country.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  235 95 -
ORIGINAL ARTICLES
Behavioural risk factors for non communicable diseases among adults in Kerala, India
TN Sugathan, CR Soman, K Sankaranarayanan
June 2008, 127(6):555-563
PMID:18765874
Full text not available  [PDF]  [PubMed]
  123 198 -
REVIEW ARTICLES
Genetic polymorphism of CYP2C19 & therapeutic response to proton pump inhibitors
AS Chaudhry, R Kochhar, KK Kohli
June 2008, 127(6):521-530
PMID:18765869
Proton pump inhibitors (PPIs) are extensively metabolized in the liver by CYP2C19, that demonstrates genetic polymorphism with 21 mutant alleles. The subjects can be divided into 2 groups with respect to CYP2C19 phenotypes viz., extensive metabolizers (EMs) and poor metabolizers (PMs) of PPIs. This division results in marked interindividual variations in the pharmacokinetics and pharmacodynamics of PPIs in the population. Intragastric pH values and the plasma concentration of PPIs after oral ingestion were significantly lower in EMs namely normal homozygotes (CYP2C19*1/*1) and heterozygotes (CYP2C19*1/*X) compared to PMs namely mutant homozygotes (CYP2C19*X/*X) where 'X' represents the mutant allele. Hence, association has been found between the genetic polymorphism of CYP2C19 and therapeutic response to PPIs. CYP2C19 polymorphism affected eradication of Helicobacter pylori using diferent PPI based eradication therapies as PM patients demonstrated significantly higher eradication rates compared to EMs. CYP2C19 genetic polymorphism also affects the therapeutic outcome of gastroesophageal reflux disease (GERD), reflux oesophagitis and duodenal ulcers. For optimal therapeutic response with PPIs, CYP2C19 pharmacogenetics should be taken into consideration. This shall help in the prescription of optimal doses of PPIs, thus paving the way for personalized medication.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  186 95 -
ORIGINAL ARTICLES
Effect of nicotine on lipid profile, peroxidation & antioxidant enzymes in female rats with restricted dietary protein
K Chattopadhyay, BD Chattopadhyay
June 2008, 127(6):571-576
PMID:18765876
Full text not available  [PDF]  [PubMed]
  110 154 -
Age composition of incriminated malaria vector in a rural foothills in West Bengal, India
G Chandra
June 2008, 127(6):607-609
PMID:18765881
Two 1 yr surveys carried out at a gap of 10 yr revealed nine anopheline species from malaria endemic foothills area of Ayodhya - Baghmindi range of West Bengal, India, with 8.4 per cent populations of Anopheles culicifacies. An. culicifacies was incriminated as vector of Plasmodium falciparum with sporozoite rate of 1.23 per cent. Studies on age composition indicated that proportion parous and daily survival rate of An. culicifacies were assessed to be 0.50 and 0.84 respectively. The survival rate per gonotrophic cycle averaged over the two year was 0.61. Rainy season was found to be the favourable period for transmission.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  168 82 -
CORRESPONDENCES
Shigellosis in Puducherry
R Dhodapkar, N Srinivas Acharya, BN Harish, SC Parija
June 2008, 127(6):621-622
PMID:18765885
Full text not available  [PDF]  [PubMed]
  98 134 -
ORIGINAL ARTICLES
Pre-operative intravenous fluid therapy with crystalloids or colloids on post-operative nausea & vomiting
S Chaudhary, AK Sethi, P Motiani, C Adatia
June 2008, 127(6):577-581
PMID:18765877
Full text not available  [PDF]  [PubMed]
  99 125 -
COMMENTARIES
Prevention of childhood obesity should be an integral part of prevention of non communicable diseases
A Ramachandran, C Snehalatha
June 2008, 127(6):514-515
PMID:18765866
Full text not available  [PDF]  [PubMed]
  107 115 -
ORIGINAL ARTICLES
Anatomy & distribution of coronary arteries in pig in comparison with man
D Sahni, GD Kaur, H Jit, I Jit
June 2008, 127(6):564-570
PMID:18765875
Full text not available  [PDF]  [PubMed]
  106 92 -
Molecular characterization of shiga like toxin-producing Escherichia coli (STEC) isolates from pigs oedema
NN Barman, R Deb, T Ramamurthy, RK Sharma, P Borah, SA Wani, D Kalita
June 2008, 127(6):602-606
PMID:18765880
Full text not available  [PDF]  [PubMed]
  100 95 -
Spread, establishment & prevalence of dengue vector Aedes aegypti (L.) in Konkan region, Maharashtra, India
PV Fulmali, A Walimbe, PV Mahadev
June 2008, 127(6):589-601
PMID:18765879
Full text not available  [PDF]  [PubMed]
  91 102 -
COMMENTARIES
Symptoms of depression in schizophrenia
T Murali, S Ravi Kumar
June 2008, 127(6):516-518
PMID:18765867
Full text not available  [PDF]  [PubMed]
  99 89 -
ORIGINAL ARTICLES
Characterisation of depression in patients with schizophrenia
A Heald, J Morris, Som D Soni
June 2008, 127(6):544-550
PMID:18765872
Full text not available  [PDF]  [PubMed]
  90 90 -
Effect of Scutellaria flavonoids on KCN-induced damages in rat pheochromocytoma PC12 cells
Ya Zhen Shang, Bo Wen Qin, Jian Jun Cheng, H Miao
June 2008, 127(6):610-615
PMID:18765882
Full text not available  [PDF]  [PubMed]
  90 79 -
Comparison of treatment regimens of kala-azar based on culture & sensitivity of amastigotes to sodium antimony gluconate
CP Thakur, S Thakur, S Narayan, A Sinha
June 2008, 127(6):582-588
PMID:18765878
Full text not available  [PDF]  [PubMed]
  81 84 -
COMMENTARIES
The safety of rubella vaccine in pregnancy
T Jacob John
June 2008, 127(6):519-520
PMID:18765868
Full text not available  [PDF]  [PubMed]
  85 73 -
CORRESPONDENCES
Infiltration of Aedes aegypti into peri-urban areas in South Andaman
AN Shriram, AP Sugunan, P Vijayachari
June 2008, 127(6):618-620
PMID:18765884
Full text not available  [PDF]  [PubMed]
  84 74 -
EDITORIAL
HPV vaccine : end to women's major health problem?
K Somasundaram
June 2008, 127(6):511-513
PMID:18765865
Full text not available  [PDF]  [PubMed]
  62 88 -
BOOK RECEIVED
Protecting health in Europe from climate change

June 2008, 127(6):624-624
Full text not available  [PDF]
  51 82 -
PUBLIC NOTICE
Public notice

June 2008, 127(6):626-626
Full text not available  [PDF]
  51 75 -
SOME FORTHCOMING SCIENTIFIC EVENTS
Some forthcoming scientific events

June 2008, 127(6):623-623
Full text not available  [PDF]
  44 65 -
ANNOUNCEMENTS
Announcements

June 2008, 127(6):625-625
Full text not available  [PDF]
  49 57 -
ORIGINAL ARTICLES
Congenital rubella syndrome in infants of women vaccinated during or just before pregnancy with measles-rubella vaccine
Mohammad H Namaei, M Ziaee, N Naseh
June 2008, 127(6):551-554
PMID:18765873
Full text not available     [PubMed]
  92 0 -
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