Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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   2008| April  | Volume 127 | Issue 4  
    Online since May 11, 2011

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Ethnobotany & ethnopharmacology of Tabernaemontana divaricata
W Pratchayasakul, A Pongchaidecha, N Chattipakorn, S Chattipakorn
April 2008, 127(4):317-335
Tabernaemontana divaricata a common garden plant in tropical countries has been used as a traditional medicine. However, no recent review articles of T. divaricata, particularly discussing its pharmacological properties, are available. This review presents the ethnobotany and ethnopharmacology of T. divaricata as well as its potential therapeutic benefits especially of the alkaloidal and non-alkaloidal constituents. Included, are the characteristics of 66 alkaloids isolated and identified from T. divaricata. Non-alkaloids including the enzymes, pyrolytic oil, hydrocarbons, terpenoid and phenolic acids are also documented. Chemotaxonomic aspects of each alkaloid as well as information regarding the pharmacology of crude extracts and individual alkaloids from T. divaricata have been assembled and appraised. The beneficial properties of T. divaricata are antioxidant, anti-infection, anti-tumour action, analgesia and the enhancement of cholinergic activity in both peripheral and central nervous systems. The augmentation of cholinergic function may be of therapeutic benefit for many neurodegenerative diseases, particularly myasthenia gravis and Alzheimer's disease.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  283 239 -
Incidence of metallo beta lactamase producing Pseudomonas aeruginosa in ICU patients
A Varaiya, N Kulkarni, M Kulkarni, P Bhalekar, J Dogra
April 2008, 127(4):398-402
Full text not available  [PDF]  [PubMed]
  86 338 -
Chloroquine : novel uses & manifestations
RG Cooper, T Magwere
April 2008, 127(4):305-316
Chloroquine (CHQ) is a cheap, relatively well tolerated drug initially developed for the treatment of malaria in the 1930s. CHQ has, however, since accrued a plethora of uses in the treatment and amelioration of several other diseases and conditions because of its lysosomotropic properties. It also has characteristic physiological and systemic effects. This review gives an overview of the history and pharmacology of CHQ, and progresses to consider some of the mechanisms that may underlie its biochemical and physiological effects. Additionally, an overview of some of the novel uses of CHQ in the treatment of viral infections and cancer are presented. The antimalarial mechanisms of CHQ were not discussed in this review. The message is that CHQ, despite its welldocumented toxicity and adverse side effects may have important future uses that are associated with its lysosomotropic and immunomodulatory mechanisms. The possibility exists therefore that CHQ might be re-introduced into regular malaria treatment.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  224 128 -
Cost of illness : evidence from a study in five resource-poor locations in India
David M Dror, O van Putten-Rademaker, R Koren
April 2008, 127(4):347-361
Full text not available  [PDF]  [PubMed]
  131 204 -
Iron deficiency anaemia in sickle cell disorders in India
D Mohanty, MB Mukherjee, RB Colah, M Wadia, K Ghosh, GP Chottray, D Jain, Y Italia, K Ashokan, R Kaul, DK Shukla, V Muthuswamy
April 2008, 127(4):366-369
Full text not available  [PDF]  [PubMed]
  111 137 -
Natural vertical transmission of dengue viruses by Aedes aegypti in Chennai, Tamil Nadu, India
N Arunachalam, SC Tewari, V Thenmozhi, R Rajendran, R Paramasivan, R Manavalan, K Ayanar, BK Tyagi
April 2008, 127(4):395-407
Full text not available  [PDF]  [PubMed]
  112 118 -
Isospora belli, Strongyloides stercoralis & hookworm multiple-infection in a person with HIV infection & normal CD4+ T-lymphocyte count
R Vignesh, Esaki Muthu Shankar, P Balakrishnan, Kailapuri G Murugavel, Paulos I Paul, R Sekar, S Solomon, N Kumarasamy
April 2008, 127(4):403-405
Full text not available  [PDF]  [PubMed]
  93 125 -
Authors' response
VV Banu Rekha, R Balasubramanian, S Swaminathan, R Ramachandran, F Rahman, V Sundaram, K Thyagarajan, N Selvakumar, AR Adhilakshmi, S Iliayas, PR Narayanan
April 2008, 127(4):408-409
Full text not available  [PDF]
  122 90 -
Changing pattern of Clostridium difficile associated diarrhoea in a tertiary care hospital : a 5 year retrospective study
R Chaudhry, L Joshy, L Kumar, B Dhawan
April 2008, 127(4):377-382
Full text not available  [PDF]  [PubMed]
  69 141 -
Factors, definitions, predictive value & Asian Indian ethnicity : complexities of the metabolic syndrome
A Misra, Naval K Vikram
April 2008, 127(4):293-296
Full text not available  [PDF]  [PubMed]
  78 127 -
Molecular appraisal of Indian animal isolates of Echinococcus granulosus
D Bhattacharya, AK Bera, BC Bera, D Pan, SK Das
April 2008, 127(4):383-387
Full text not available  [PDF]  [PubMed]
  92 98 -
Factor analysis of metabolic syndrome using direct measurement of insulin resistance in Chinese with different degrees of glucose tolerance
CZ Wu, JD Lin, JC Li, FC Hsiao, CH Hsieh, SW Kuo, YJ Hung, CH Lu, CT He, D Pei
April 2008, 127(4):336-343
Full text not available  [PDF]  [PubMed]
  118 71 -
Detection of extended spectrum beta-lactamase production in clinical isolates of Klebsiella spp
A Jain, R Mondal
April 2008, 127(4):344-346
Full text not available  [PDF]  [PubMed]
  84 101 -
Cassia occidentalis toxicity causes recurrent outbreaks of brain disease in children in Saharanpur
RS Panwar, N Kumar
April 2008, 127(4):413-414
Full text not available  [PDF]  [PubMed]
  74 104 -
ESBLs detection in clinical microbiology : why & how?
N Taneja, M Sharma
April 2008, 127(4):297-300
Full text not available  [PDF]  [PubMed]
  73 94 -
Effect of intraarticular injection of lornoxicam on the articular cartilage & synovium in rat
F Saricaoglu, D Dal, P Atilla, Alper B Ěskit, Ö Tarhan, E Asan, Ülkü Aypar
April 2008, 127(4):362-365
Full text not available  [PDF]  [PubMed]
  78 89 -
Urinary & serum oxalate determination by oxalate oxidase immobilized on to affixed arylamine glass beads
S Godara, CS Pundir
April 2008, 127(4):370-376
Full text not available  [PDF]  [PubMed]
  81 83 -
Bacterial infections in burn patients
O Oncul, A Acar
April 2008, 127(4):415-415
Full text not available  [PDF]  [PubMed]
  69 88 -
Authors' response
A Ekrami, E Kalantar
April 2008, 127(4):416-416
Full text not available  [PDF]
  69 85 -
Towards equitable health care : drug prices, and beyond
K Satyanarayana
April 2008, 127(4):301-304
Full text not available  [PDF]  [PubMed]
  74 76 -
Some forthcoming scientific events

April 2008, 127(4):422-422
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  49 96 -
Urgent reforms needed to revive impact factor of India's medical journals
G Agoramoorthy
April 2008, 127(4):410-412
Full text not available  [PDF]  [PubMed]
  58 86 -
Sputum conversion at the end of intensive phase treatment of pulmonary tuberculosis patients with diabetes mellitus or HIV infection
D Aggarwal, PR Mohapatra
April 2008, 127(4):408-408
Full text not available  [PDF]  [PubMed]
  61 82 -
A web based module for capturing acute coronary events in Indian hospitals
M Sharma, LM Nath, R Tandon, B Shah
April 2008, 127(4):289-292
Full text not available  [PDF]  [PubMed]
  67 73 -
Expression of co-stimulatory molecules B7.1 & B7.2 on macrophages infected with various strains of Mycobacterium tuberculosis & its influence on T-cell apoptosis
P Rajavelu, Sulochana D Das
April 2008, 127(4):388-394
Full text not available  [PDF]  [PubMed]
  54 77 -
Basic methods of medical research

April 2008, 127(4):421-421
Full text not available  [PDF]
  39 72 -
Imipenem-EDTA disk method for rapid identification of metallo-beta-lactamase producing Gram-negative bacteria
U Chaudhary, H Bhaskar, M Sharma
April 2008, 127(4):406-407
Full text not available     [PubMed]
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April 2008, 127(4):422-422
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