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| BOOK REVIEWS |
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| Bedside clinics in medicine
S Varma
May 2008, 127(5):509-509 Full text not available [PDF] |
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| REVIEW ARTICLE |
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| Disease associations of mannose-binding lectin & potential of replacement therapy
K Gupta, RK Gupta, K Hajela
May 2008, 127(5):431-440
PMID:18653905Mannose-binding lectin (MBL) is an important component of the immune defence able to bind to repeating mannose based structural patterns typical of microbial surface (bacteria, viruses, fungi, parasites) leading to opsonization and phagocytosis, and activation of the complement pathway resulting in lysis of the pathogen. MBL thus plays a very important role in the first line of host immune response. MBL deficiency has been implicated in susceptibility and modulating the severity in viral, bacterial, fungal, and protozoan infections. High MBL levels, on the contrary might be helpful to intracellular organisms, which take the advantage of C3 opsonization and C3 receptor on monocytes/macrophages to enter their host. MBL replacement therapy to help patients with MBL deficiency has undergone phase I clinical trials. Phase II and III trials and production of recombinant MBL for replacement therapy are currently underway. |
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| ORIGINAL ARTICLES |
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| Tetany in kala azar patients treated with paromomycin
CP Thakur
May 2008, 127(5):489-493
PMID:18653914Paromomycin, an aminoglycoside, is known to cause several side effects like nephrotoxicity and ototoxicity like other aminoglycosides but tetany has not been reported. Three cases of tetany were detected in the patients of kala-azar treated with paromomycin. They were promptly treated with intravenous 10 per cent calcium gluconate and tetany was relieved immediately and treatment with paromomycin continued with oral calcium supplement. After completion of 21 days treatment with paromomycin patients' splenic aspirates were free of parasites. Paromomycin may cause temporary tubular damage leading to calcium wasting in urine and hypocalcaemia resulting in tetany. Prompt detection of symptoms and intravenous calcium gluconate treatment promptly reverse the situation. |
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| Pharmacodynamics & toxicological profile of PartySmart, a herbal preparation for alcohol hangover in Wistar rats
MV Venkataranganna, S Gopumadhavan, R Sundaram, G Peer, SK Mitra
May 2008, 127(5):460-466
PMID:18653909 |
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| Trend of antibiotic resistance of Vibrio cholerae strains from East Delhi
S Das, R Saha, Iqbal R Kaur
May 2008, 127(5):478-482
PMID:18653912 |
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| Total body muscle mass estimation from bioelectrical impedance analysis & simple anthropometric measurements in Indian men
R Kuriyan, T Thomas, AV Kurpad
May 2008, 127(5):441-446
PMID:18653906 |
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| Comorbidities among HIV-infected injection drug users in Chennai, India
SS Solomon, CS Hawcroft, P Narasimhan, R Subbaraman, AK Srikrishnan, AJ Cecelia, M Suresh Kumar, S Solomon, JE Gallant, DD Celentano
May 2008, 127(5):447-452
PMID:18653907 |
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| Estimation of faecal carriage of Clostridium difficile in patients with ulcerative colitis using real time polymerase chain reaction
R Balamurugan, V Balaji, Balakrishnan S Ramakrishna
May 2008, 127(5):472-477
PMID:18653911 |
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| In vitro effect of four herbal plants on the motility of Brugia malayi microfilariae
KN Sahare, V Anandharaman, VG Meshram, SU Meshram, D Gajalakshmi, K Goswami, MV Reddy
May 2008, 127(5):467-471
PMID:18653910 |
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| CORRESPONDENCES |
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| Hepatitis B in India : Systematic review & report of the 'IMA sub-committee on immunization'
Jacob M Puliyel, P Rastogi, Joseph L Mathew
May 2008, 127(5):494-497
PMID:18653915 |
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| BOOK REVIEWS |
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| Global age-friendly cities: A guide
Damodar Suar
May 2008, 127(5):507-508 Full text not available [PDF] |
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| COMMENTARIES |
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| Co-morbidities among injecting drug users with HIV in India--challenges in clinical management
K Sarkar, S Chakrabarti
May 2008, 127(5):428-430
PMID:18653904 |
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| Bioimpedance and the estimation of human skeletal muscle mass
PS Shetty
May 2008, 127(5):426-427
PMID:18653903 |
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| CORRESPONDENCES |
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| Who benefits from WHO recommendations on vaccines?
JL Mathew
May 2008, 127(5):504-505
PMID:18653918 |
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| ORIGINAL ARTICLES |
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| Evaluation of conventional & serological methods for rapid diagnosis of cryptococcosis
DC Saha, I Xess, N Jain
May 2008, 127(5):483-488
PMID:18653913 |
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| CORRESPONDENCES |
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| The nexus & the ills afflicting the vaccination practices
Vipin M Vashishtha
May 2008, 127(5):502-503
PMID:18653917 |
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| Authors' response
Ajit Avasthi, SC Varma, P Kulhara, R Nehra, S Grover, S Sharma
May 2008, 127(5):506-506 Full text not available [PDF] |
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| PRIME-MD health questionnaire for diagnosis of common mental disorders
R Jacob
May 2008, 127(5):506-506
PMID:18653920 |
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| ORIGINAL ARTICLES |
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| N-myc downstream-regulated gene 1 as a downregulated target gene of PTEN in the controlling of tumourigenesis in endometrioid carcinoma
S Li, J Chen, Z Yang, G Lu, H Tang, H Hu
May 2008, 127(5):453-459
PMID:18653908 |
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| EDITORIAL |
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| The encouraging 'COURAGE'
S Singh, VK Bahl
May 2008, 127(5):423-425
PMID:18653902 |
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| CORRESPONDENCES |
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| Vaccination policy for benefit and profit, public & private
T Jacob John
May 2008, 127(5):498-501
PMID:18653916 |
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| SOME FORTHCOMING SCIENTIFIC EVENTS |
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| Some forthcoming scientific events
May 2008, 127(5):510-510 Full text not available [PDF] |
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| ANNOUNCEMENT |
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| Announcement
May 2008, 127(5):510-510 Full text not available [PDF] |
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