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April 2010 Volume 131 | Issue 4
Page Nos. 475-595
Online since Saturday, April 16, 2011
Accessed 10,899 times.
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EDITORIALS |
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Counting malaria out - what progress? |
p. 475 |
Nilanthi de Silva, R Wickremasinghe PMID:20424295 |
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Nutritional composition & health benefits of organic foods - using systematic reviews to question the available evidence |
p. 478 |
Alan D Dangour, E Allen, K Lock, R Uauy PMID:20424296 |
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COMMENTARIES |
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Exposure to low-dose mercury (from thimerosal) & premature puberty - a new avenue for research with the vaccine safety datalink |
p. 481 |
José G Dórea PMID:20424297 |
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Genome-based diagnosis of genetic disease |
p. 484 |
Ching- Wan Lam PMID:20424298 |
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REVIEW ARTICLE |
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Clinical spectrum & pathogenesis of Clostridium difficile associated diseases  |
p. 487 |
C Vaishnavi PMID:20424299Clostridium difficile is the major aetiological agent of antibiotic associated diarrhoea and colitis. The majority of hospitalized patients infected by C. difficile are asymptomatic carriers who serve as silent reservoirs for continued C. difficile contamination of the hospital environment. C. difficile associated disease (CDAD) is a serious condition with mortality up to 25 per cent in frail elderly people. C. difficile infection may present itself in several forms with both colonic and extracolonic manifestations. Several factors are involved in determining whether or not a patient develops C. difficile infection. These include factors related to the pathogen as well as the host. Transmission of C. difficile can be endogenous or exogenous. Colonization of the pathogen occurs when the gut flora gets disrupted due to various factors. The main virulence factors for CDAD are the two potent toxins: toxin A and toxin B which share 63 per cent of amino acid sequence homology and act on small guanosine triphosphate binding proteins. The emergence of the global hypervirulent C. difficile strain has been a cause of concern. Diagnosis of CDAD infection can be done by detection of C. difficile toxin in the stool specimen. Vancomycin is the drug of choice for severely ill patient, whereas metronidazole can be used for mild to moderately ill patients. Clinical spectrum, the factors precipitating CDAD, pathogenesis, diagnostic assay and treatment of the disease are reviewed. |
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ORIGINAL ARTICLES |
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Thimerosal exposure & increasing trends of premature puberty in the vaccine safety datalink |
p. 500 |
David A Geier, Heather A Young, Mark R Geier PMID:20424300 |
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Novel mutations in Indian patients with autosomal recessive infantile malignant osteopetrosis |
p. 508 |
Shubha R Phadke, B Fischer, N Gupta, P Ranganath, M Kabra, U Kornak PMID:20424301 |
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Prevalence of health related disability among community dwelling urban elderly from middle socioeconomic strata in Bangaluru, India |
p. 515 |
K Srinivasan, M Vaz, T Thomas PMID:20424302 |
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Paraoxonase gene Q192R & L55M polymorphisms in Indians with acute myocardial infarction & association with oxidized low density lipoprotein |
p. 522 |
R Lakshmy, D Ahmad, Rani Ann Abraham, M Sharma, K Vemparala, S Das, K Srinath Reddy, D Prabhakaran PMID:20424303 |
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Efficacy of cabergoline on rapid escalation of dose in men with macroprolactinomas |
p. 530 |
A Bhansali, R Walia, P Dutta, N Khandelwal, R Sialy, S Bhadada PMID:20424304 |
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Transplantation of retinoic acid treated murine embryonic stem cells & behavioural deficit in Parkinsonian rats |
p. 536 |
F Fathi, T Altiraihi, Seyed Javad Mowla, M Movahedin PMID:20424305 |
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Clinical & molecular characterization of human TT virus in different liver diseases |
p. 545 |
M Asim, R Singla, RK Gupta, P Kar PMID:20424306 |
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Serum C3d levels in tropical pulmonary eosinophilia |
p. 555 |
D Ray, S Subramanyam, S Hari Krishna, VD Ramanathan PMID:20424307 |
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Infectious aetiology of congenital cataract based on TORCHES screening in a tertiary eye hospital in Chennai, Tamil Nadu, India |
p. 559 |
B Mahalakshmi, K Lily Therese, U Devipriya, V Pushpalatha, S Margarita, HN Madhavan PMID:20424308 |
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Detection, amplification & sequence homology of sodC in clinical isolates of Salmonella sp. |
p. 565 |
MK Sanjay, SM Shrideshikan, MS Usha, A Philipraj, SM Gaddad, CT Shivannavar PMID:20424309 |
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Post-operative endophthalmitis : Antibiogram & genetic relatedness between Pseudomonas aeruginosa isolates from patients & phacoemulsifiers |
p. 571 |
G Satpathy, D Patnayak, Jeewan Singh Titiyal, N Nayak, R Tandon, N Sharma, Rasik Behari Vajpayee PMID:20424310 |
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Iron regulated outer membrane proteins (IROMPs) as potential targets against carbapenem-resistant Acinetobacter spp. isolated from a Medical Centre in Malaysia |
p. 578 |
Wong Eng Hwa, G Subramaniam, Marzida Bt Mansor, Ong Siok Yan, Deepa Anbazhagan, Sekaran Shamala Devi PMID:20424311 |
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CORRESPONDENCES |
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Fatal Burkholderia pseudomallei septicaemia in a patient with diabetes |
p. 584 |
RD Kulkarni, P Jain, GS Ajantha, J Shetty, S Chunchanur, C Shubhada PMID:20424312 |
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Scoring more than ten plus century - Antiquity in gerontology? |
p. 586 |
Jitendra Kumar Sinha, S Ghosh PMID:20424313 |
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Incomplete reporting of research in press releases : et tu, WHO? |
p. 588 |
J Puliyel, JL Mathew, R Priya PMID:20424314 |
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Research oriented medical education in India |
p. 590 |
S Aggarwal PMID:20424315 |
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BOOK REVIEWS |
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Book Reviews |
p. 591 |
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SOME FORTHCOMING SCIENTIFIC EVENTS |
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Some forthcoming scientific events |
p. 594 |
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ANNOUNCEMENTS |
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Announcements |
p. 595 |
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