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January 2009 Volume 129 | Issue 1
Page Nos. 1-115
Online since Wednesday, April 20, 2011
Accessed 4,592 times.
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EDITORIAL |
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Shift to Th2 cytokine response in dengue haemorrhagic fever |
p. 1 |
UC Chaturvedi PMID:19287050 |
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COMMENTARIES |
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Ectopic Cushing's syndrome : some facts |
p. 4 |
R Salvatori PMID:19287051 |
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Challenges in providing HIV care to paediatric age group in India |
p. 7 |
P Haldar, DC S Reddy PMID:19287052 |
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REVIEW ARTICLES |
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Animal models of tuberculosis for vaccine development |
p. 11 |
UD Gupta, VM Katoch PMID:19287053Animal models for testing different vaccine candidates have been developed since a long time for studying tuberculosis. Mice, guinea pigs and rabbits are animals most frequently used. Each model has its own merits for studying human tuberculosis, and none completely mimics the human disease. Different animal models are being used depending upon the availability of the space, trained manpower as well as other resources. Efforts should continue to develop a vaccine which can replace/outperform the presently available vaccine BCG. |
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Informed consent & ethical issues in paediatric psychopharmacology |
p. 19 |
S Malhotra, BN Subodh PMID:19287054Issues relating to informed consent and ethics in paediatric psychopharmacology limit research in this population. Children vary in their levels of cognitive development, and presence of psychiatric disorder may further impair their ability to give informed consent. In decisional impairment subjects, various methods used for consent are assent/dissent; inclusion of advance directives; and/or alternative decision-makers. India is emerging as a new market for clinical trials in recent years. Moreover, in India the sociocultural realities are different from those in the western countries making it necessary for professionals to be cautious in conducting drug trials. In this review, issues regarding informed consent in children and adolescent with psychiatric diagnosis are discussed for information, discussion and debate by professionals, parents, society and legal experts to create awareness and to facilitate development of guidelines that are appropriate and applicable to the Indian system. |
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ORIGINAL ARTICLES |
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Ectopic Cushing's syndrome : experience from a tertiary care centre |
p. 33 |
A Bhansali, R Walia, SS Rana, P Dutta, BD Radotra, N Khandelwal, SK Bhadada PMID:19287055 |
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Demographic & clinical profile of HIV infected children accessing care at Tambaram, Chennai, India |
p. 42 |
S Rajasekaran, L Jeyaseelan, K Raja, N Ravichandran PMID:19287056 |
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Improved estimates of India's HIV burden in 2006 |
p. 50 |
A Pandey, Dandu C Reddy, Peter D Ghys, M Thomas, D Sahu, M Bhattacharya, Kanchan D Maiti, F Arnold, S Kant, A Khera, R Garg PMID:19287057 |
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Establishment of T-lymphocyte subset reference intervals in a healthy adult population in Chennai, India |
p. 59 |
KG Murugavel, P Balakrishnan, J Mohanakrishnan, SS Solomon, EM Shankar, Sandeep Pulimi Muthu Sundaram, N Kumarasamy, E Piwowar-Manning, E Livant, KH Mayer, SP Thyagarajan, S Solomon PMID:19287058Estimation of CD4+ T-lymphocytes continues to be an important aspect for monitoring HIV disease progression and response to antiretroviral therapy. Most of the diagnostic laboratories often rely on western text books for CD4+ T-lymphocyte reference values, which could, often be unreliable for usage in local settings. Therefore, we attempted to establish the reference values for T-lymphocyte subsets among healthy adults in a cross-sectional study carried out at the YRG Centre for AIDS Research and Education (YRG CARE) in Chennai, south India, in 213 (84 female and 129 male) healthy, HIV-1/2 seronegative adults as volunteers. Whole blood specimens were processed for CD4+, CD8+ T-lymphocyte estimation and haematological parameters. The established range of CD4+ T-lymphocyte counts for men and women were 383-1347 cells/microl (mean 865 and median 845 cells/microl) and 448-1593 cells/microl (mean 1021 and median 954 cells/microl), respectively. Women had significantly higher absolute CD4+ Tlymphocyte counts (P<0.001) and CD4+:CD8+ T-lymphocyte ratio as compared to men. The established normal range of CD4+ T-lymphocyte % was 21-59 (mean 40.2 and median 40.1). The influence of age was not observed in any of the parameters except CD4+/CD8+ T-lymphocyte ratio with the >45 yr age group. Further studies with greater sample size may be required to define the staging of HIV disease in relation to the normal CD4 T-lymphocyte count in the general population. |
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Role of acute viral hepatitis as a confounding factor in antituberculosis treatment induced hepatotoxicity |
p. 64 |
P Sarda, SK Sharma, A Mohan, G Makharia, A Jayaswal, RM Pandey, S Singh PMID:19287059 |
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Endothelial nitric oxide synthase (eNOS) Glu298-->Asp polymorphism (G894T) among south Indians |
p. 68 |
NS Nishevitha, T Angeline, N Jeyaraj PMID:19287060 |
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Murine monoclonal anti-H as typing reagent |
p. 72 |
YS Iyer, K Vasantha, V Pujari, S Jadhav, K Ghosh PMID:19287061 |
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Systemic manifestations in chronic arsenic toxicity in absence of skin lesions in West Bengal |
p. 75 |
KK Majumdar, DN Guha Mazumder, N Ghose, A Ghose, S Lahiri PMID:19287062 |
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An exploratory clinical study of adult attention deficit/hyperactivity disorder from India |
p. 83 |
P Sitholey, V Agarwal, S Sharma PMID:19287063 |
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Expression of class III β-tubulin in colorectal carcinomas : an immunohistochemical study using TU-20 & TuJ-1 antibody. |
p. 89 |
T Jirásek, Š Cipro, A Musilová, M Kubecová, V Mandys PMID:19287064 |
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An increase in enteric fever cases due to Salmonella Paratyphi A in & around Chandigarh |
p. 95 |
V Gupta, J Kaur, J Chander PMID:19287065 |
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Addition of isovitalex in chocolate agar for the isolation of Haemophilus influenzae |
p. 99 |
SK Saha, AH Baqui, GL Darmstadt, M Islam, SE Arifeen, M Santosham, T Nagatake, RE Black PMID:19287066 |
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CORRESPONDENCES |
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Newer strategies for the kala-azar elimination programme in India |
p. 102 |
CP Thakur, Amit Kumar Meenakshi Thakur, S Thakur PMID:19287067 |
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PCR on formalin-fixed necropsy tissues to diagnose leptospirosis |
p. 105 |
V Manu, S Roy, Anita R DuttaRoy, S Sharma, P Vijayachari, VK Kataria, SC Seghal PMID:19287068 |
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Association of mutations in rpsL gene with high degree of streptomycin resistance in clinical isolates of Mycobacterium tuberculosis in India |
p. 108 |
R Das, P Gupta, P Singh, DS Chauhan, K Katoch, VM Katoch PMID:19287069 |
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BOOK REVIEWS |
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Monitoring and evaluation of mental health policies and plans |
p. 111 |
Shridhar Sharma |
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Evaluation of certain food additives and contaminants |
p. 112 |
Kalpgam Polasa |
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BOOK RECEIVED |
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Book Received |
p. 114 |
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SOME FORTHCOMING SCIENTIFIC EVENTS |
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Some Forthcoming Scientific Events |
p. 115 |
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ANNOUNCEMENT |
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Announcement |
p. 115 |
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