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July 2008 Volume 128 | Issue 1
Page Nos. 1-91
Online since Wednesday, May 4, 2011
Accessed 4,740 times.
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EDITORIAL |
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Malaria in the South-East Asia region : myth & the reality |
p. 1 |
Jai P Narain PMID:18820349 |
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COMMENTARIES |
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Natural reservoir, zoonotic tuberculosis & interface with human tuberculosis : an unsolved question |
p. 4 |
Mridula Bose PMID:18820350 |
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Changing epidemiology of hepatitis A infection |
p. 7 |
A Gupta, Y Chawla PMID:18820351 |
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PKDL - a drug related phenomenon? |
p. 10 |
Simon L Croft PMID:18820352 |
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REVIEW ARTICLES |
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Targeting protein acetylation for improving cancer therapy |
p. 13 |
BS Dwarakanath, A Verma, AN Bhatt, VS Parmar, HG Raj PMID:18820353Acetylation is one of the most important post-translational modification of proteins determining the structure, function and intracellular localization that plays an important role in the signal transduction pathways related to diverse cell functions, both during unstimulated and stress conditions. Protein acetylation in cells is regulated by a co-ordinated action of histone acetyl transferases (HAT) and histone deacetylases(HDAC) that ensures the maintenance of homeostasis and execution of activities related to damage response viz. DNA repair, cell cycle delay, apoptosis and senescence. Since inhibition of histone deacetylation, stalls the progress of many nuclear events including proliferation and damage response events on the one hand and the levels of deacetylases are elevated in many tumours on the other. Histone deacetylase has been among the targets for the development of anticancer drugs and adjuvant. The recent observation showing acetylation of proteins by calreticulin (an endoplasmic reticulum resident protein) with a high efficiency when polyphenolic acetates are the acetyl group donating molecules and acetyl CoA as weak substrate extends the realm of protein acetylation beyond HAT/HDAC combination. Elucidation of the relative roles of HAT/HDAC mediated acetylation viz. a calreticulin mediated acetylation in cell function under a variety of stress conditions would hold key to the design of drugs targeting protein acetylation system. |
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Biological control of mosquito populations through frogs : opportunities & constrains |
p. 22 |
K Raghavendra, P Sharma, AP Dash PMID:18820354The use of frogs and tadpoles for disease vector control is still largely unexplored. Frogs are an important part of the ecosystem with a role for insect and pest control including mosquitoes. Available information suggests the existence of many direct and indirect factors affecting the growth and survival of both prey and predators. Other controphic species that have influence on this relationship also show considerable effect. Still, the associations of different prey and predator relationships in the environment to assess the feasibility of use of a species as biocontrol agent for vector control and management. However, frogs cannot be used as an independent intervention for disease vector control and more research is needed to use them effectively for mosquito control. |
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ORIGINAL ARTICLES |
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Isolation of Mycobacterium bovis & M. tuberculosis from cattle of some farms in north India--possible relevance in human health  |
p. 26 |
K Srivastava, DS Chauhan, P Gupta, HB Singh, VD Sharma, VS Yadav, Sreekumaran , SS Thakral, JS Dharamdheeran, P Nigam, HK Prasad, VM Katoch PMID:18820355 |
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Investigation of a hepatitis A outbreak in children in an urban slum in Vellore, Tamil Nadu, using geographic information systems |
p. 32 |
Thuppal V Sowmyanarayanan, A Mukhopadhya, BP Gladstone, R Sarkar, G Kang PMID:18820356 |
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Impact of amphotericin-B in the treatment of kala-azar on the incidence of PKDL in Bihar, India |
p. 38 |
CP Thakur, A Kumar, G Mitra, S Thakur, PK Sinha, P Das, SK Bhattacharya, A Sinha PMID:18820357 |
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Detection & management of anaemia in pregnancy in an urban primary health care institution |
p. 45 |
Anshu Sharma, Rita Patnaik, Suman Garg, Prema Ramachandran PMID:18820358 |
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Detection & molecular confirmation of a focus of Plasmodium malariae in Arunachal Pradesh, India |
p. 52 |
PK Mohapatra, A Prakash, DR Bhattacharyya, BK Goswami, A Ahmed, B Sarmah, J Mahanta PMID:18820359 |
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Incidence of Haemophilus influenzae type b meningitis in India |
p. 57 |
S Minz, V Balraj, MK Lalitha, N Murali, T Cherian, G Manoharan, S Kadirvan, A Joseph, MC Steinhoff PMID:18820360 |
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Antifilarial activity of Caesalpinia bonducella against experimental filarial infections |
p. 65 |
RL Gaur, MK Sahoo, S Dixit, N Fatma, S Rastogi, DK Kulshreshtha, RK Chatterjee, PK Murthy PMID:18820361 |
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Expression of cell surface markers on methicillin resistant Staphylococcus aureus stimulated lymphocytes |
p. 71 |
I Fidan, E Yesilyurt, B Erdal, S Yolbakan, T Imir PMID:18820362 |
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CORRESPONDENCES |
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Prevalence & predictors of alcohol use among college students in Ludhiana, Punjab, India |
p. 79 |
V Khosla, KR Thankappan, GK Mini, PS Sarma PMID:18820363 |
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Rolling back malaria is possible |
p. 82 |
V Dev, GC Doley, AP Dash PMID:18820364 |
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Solution to contentious issue of Article 31(f) of TRIPS agreement |
p. 84 |
MD Janodia, D Sreedhar, VS Ligade, N Udupa PMID:18820365 |
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Amendment of Article 31(f) is far from a 'solution' |
p. 85 |
Sadhana Srivastava, K Satyanarayana |
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NACO must clean up phony NGOs in India |
p. 87 |
D Gene Pace, O Bagasra PMID:18820367 |
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BOOK REVIEW |
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Global tuberculosis control 2008: Surveillance, planning, financing |
p. 89 |
D Behera |
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SOME FORTHCOMING SCIENTIFIC EVENTS |
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Some forthcoming scientific events |
p. 91 |
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ANNOUNCEMENT |
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Announcement |
p. 91 |
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