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November 2006 Volume 124 | Issue 5
Page Nos. 467-596
Online since Friday, May 20, 2011
Accessed 5,632 times.
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EDITORIALS |
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The curse of dengue |
p. 467 |
UC Chaturvedi PMID:17213511 |
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Chikungunya fever : clinical manifestations & management |
p. 471 |
A Mohan PMID:17213512 |
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Vector biology of dengue & chikungunya viruses |
p. 475 |
DT Mourya, P Yadav PMID:17213513 |
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Addressing the diabetes pandemic : a comprehensive approach |
p. 481 |
Mary Margaret Huizinga, Russell L Rothman PMID:17213514 |
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COMMENTARIES |
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Whither autologous blood predonations? |
p. 485 |
A Mijovic PMID:17213515 |
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Protect the health of health care workers |
p. 488 |
T Jacob John PMID:17213516 |
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REVIEW ARTICLE |
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Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine  |
p. 491 |
SC Pradhan, C Girish PMID:17213517Silymarin, a flavonolignan from 'milk thistle' (Silybum marianum) plant is used almost exclusively for hepatoprotection and amounts to 180 million US dollars business in Germany alone. In this review we discuss about its safety, efficacy and future uses in liver diseases. The use of silymarin may replace the polyherbal formulations and will avoid the major problems of standardization, quality control and contamination with heavy metals or bacterial toxins. Silymarin consists of four flavonolignan isomers namely--silybin, isosilybin, silydianin and silychristin. Among them, silybin being the most active and commonly used. Silymarin is orally absorbed and is excreted mainly through bile as sulphates and conjugates. Silymarin offers good protection in various toxic models of experimental liver diseases in laboratory animals. It acts by antioxidative, anti-lipid peroxidative, antifibrotic, anti-inflammatory, membrane stabilizing, immunomodulatory and liver regenerating mechanisms. Silymarin has clinical applications in alcoholic liver diseases, liver cirrhosis, Amanita mushroom poisoning, viral hepatitis, toxic and drug induced liver diseases and in diabetic patients. Though silymarin does not have antiviral properties against hepatitis virus, it promotes protein synthesis, helps in regenerating liver tissue, controls inflammation, enhances glucuronidation and protects against glutathione depletion. Silymarin may prove to be a useful drug for hepatoprotection in hepatobiliary diseases and in hepatotoxicity due to drugs. The non traditional use of silymarin may make a breakthrough as a new approach to protect other organs in addition to liver. As it is having a good safety profile, better patient tolerability and an effective drug at an affordable price, in near future new derivatives or new combinations of this drug may prove to be useful. |
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ORIGINAL ARTICLES |
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Feasibility of pre-operative autologous blood donation in Indian patients with elective orthopaedic surgery |
p. 505 |
K Saluja, N Marwaha, B Thakral, V Goni, RR Sharma, GD Puri PMID:17213518 |
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Injection practices in the formal & informal healthcare sectors in rural north India |
p. 513 |
M Kermode, V Muani PMID:17213519 |
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Correlation between methotrexate efficacy & toxicity with C677T polymorphism of the methylenetetrahydrofolate gene in rheumatoid arthritis patients on folate supplementation |
p. 521 |
P Aggarwal, S Naik, KP Mishra, A Aggarwal, R Misra PMID:17213520 |
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Insulin resistance & secretion in subjects with normal fasting plasma glucose |
p. 527 |
CH Hsieh, YJ Hung, CZ Wu, SS Lee, CH Lee, CY Chen, JC Li, SW Kuo, KL Kuo, D Pei PMID:17213521 |
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Effect of environmental iodine deficiency (EID) on foetal growth in Nigeria |
p. 535 |
SC Das, AZ Mohammed, S Al-Hassan, AA Otokwula, UP Isichei PMID:17213522 |
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Assessment of mammographic density changes on plain film mammograms in postmenopausal women on hormone replacement therapy |
p. 545 |
S Orguc, C Goktan, Gulgun Yilmaz Ovali, O Karaer, S Oruc PMID:17213523 |
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Immune status of health care personnel & post vaccination analysis of immunity against rubella in an eye hospital |
p. 553 |
Thanapal Amala Rajasundari, K Chandrasekar, P Vijayalakshmi, V Muthukkaruppan PMID:17213524 |
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Changing trends in sexually transmitted infections at a Regional STD Centre in north India  |
p. 559 |
K Ray, M Bala, SM Gupta, N Khunger, P Puri, S Muralidhar, J Kumar PMID:17213525 |
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Immunoreactive outer membrane proteins of Leptospira interrogans serovar Canicola strain Hond Utrecht IV |
p. 569 |
R Amutha, P Chaudhuri, Amar P Garg, PS Cheema, SK Srivastava PMID:17213526 |
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Rapid detection of enterotoxigenic Bacteroides fragilis in diarrhoeal faecal samples |
p. 575 |
N Sharma, R Chaudhry PMID:17213527 |
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CORRESPONDENCES |
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Skewed sex ratio in India  |
p. 583 |
A Halder PMID:17213528 |
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Fluoroquinolone resistance among Salmonella enterica serovar Paratyphi A in Pondicherry |
p. 585 |
BN Harish, GA Menezes, K Sarangapani, SC Parija PMID:17213529 |
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Antimicrobial resistance profile of Pseudomonas aeruginosa producing metallo-beta-lactamases |
p. 588 |
Vandana A Agarwal, Shruti A Dongre, Rajaram M Powar PMID:17213530 |
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BOOK REVIEWS |
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Mental disorders in children and adolescents: Needs and strategies for intervention |
p. 591 |
Shoba Srinath |
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The European health report 2005, Public health action for healthier children and populations |
p. 592 |
John Powles |
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SOME FORTHCOMING SCIENTIFIC EVENTS |
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Some forthcoming scientific events |
p. 594 |
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ANNOUNCEMENTS |
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Announcements |
p. 596 |
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