Indian Journal of Medical Research

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 151  |  Issue : 1  |  Page : 47--58

Comparison of plasma adipocytokines & C-reactive protein levels in healthy schoolgoing adolescents from private & government-funded schools of Delhi, India


Shraddha Chakraborty1, Gauri Prasad1, Raman Kumar Marwaha2, Analabha Basu3, Nikhil Tandon4, Dwaipayan Bharadwaj5 
1 Genomics & Molecular Medicine Unit, CSIR-Institute of Genomics & Integrative Biology; Academy of Scientific & Innovative Research, CSIR-Institute of Genomics & Integrative Biology South Campus, New Delhi, India
2 Department of Endocrinology, International Life Sciences Institute, New Delhi, India
3 Statistical & Computational Genomics, National Institute of Biomedical Genomics, Kalyani, West Bengal, India
4 Department of Endocrinology & Metabolism, All India Institute of Medical Sciences, New Delhi, India
5 Academy of Scientific & Innovative Research, CSIR-Institute of Genomics & Integrative Biology South Campus; Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India

Correspondence Address:
Dr Dwaipayan Bharadwaj
Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi 110 067
India

Background & objectives: Obesity-mediated chronic inflammatory state is primarily governed by lifestyle and food habits in adolescents and marked by alterations in the level of various inflammatory markers. This cross-sectional study was aimed to compare the inflammatory status of healthy Indian adolescents vis-à-vis their obesity profile. The inflammatory state of urban adolescents attending private and government-funded schools, and the relationship between inflammatory marker levels and anthropometric indices in the study participants from both groups were examined. Methods: A total of 4438 study participants (10-17 yr) were chosen from various schools of Delhi, India, and their anthropometric parameters were measured. Plasma adipocytokines (adiponectin, leptin and resistin) of the study participants were measured by enzyme-linked immunosorbent assay, and plasma C-reactive protein (CRP) levels were assayed by a biochemical analyzer. Metabolic syndrome-related risk factors such as waist circumference, hip circumference (HC), fasting glucose, fasting insulin, Homeostatic Model Assessment of Insulin Resistance, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol and triglycerides of normal-weight adolescents were also evaluated. Results: The level of leptin and CRP increased with increasing adiposity, whereas adiponectin levels were found to be negatively related to obesity. All plasma cytokine levels (adiponectin, leptin and resistin) were significantly elevated in female than male adolescents. Age-based classification revealed a distinct trend of variability in the levels of all the inflammatory markers among adolescents of varying age groups. Significant differences were observed between private and government schoolgoing adolescents in terms of anthropometric and inflammatory parameters, with higher adiposity indices in the former group. The relationship of plasma adipokine and CRP levels with various adiposity indices was found to be distinctly different between private and government schoolgoing students. Interpretation & conclusions: Inflammatory markers were significantly elevated in overweight/obese adolescents. The socio-economic condition of urban Indian schoolgoing adolescents reflecting lifestyle transition has profound effects on their adiposity indices and inflammatory states. Longitudinal studies in different regions of the country need to be done to further confirm the findings.


How to cite this article:
Chakraborty S, Prasad G, Marwaha RK, Basu A, Tandon N, Bharadwaj D. Comparison of plasma adipocytokines & C-reactive protein levels in healthy schoolgoing adolescents from private & government-funded schools of Delhi, India.Indian J Med Res 2020;151:47-58


How to cite this URL:
Chakraborty S, Prasad G, Marwaha RK, Basu A, Tandon N, Bharadwaj D. Comparison of plasma adipocytokines & C-reactive protein levels in healthy schoolgoing adolescents from private & government-funded schools of Delhi, India. Indian J Med Res [serial online] 2020 [cited 2020 Sep 26 ];151:47-58
Available from: http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2020;volume=151;issue=1;spage=47;epage=58;aulast=Chakraborty;type=0