Year : 2019 | Volume
: 150 | Issue : 4 | Page : 359--364
Statins & risk of Clostridium difficile infection: A meta-analysis
Karn Wijarnpreecha1, Panadeekarn Panjawatanan2, Charat Thongprayoon1, Patompong Ungprasert3
1 Department of Internal Medicine, Bassett Medical Center, Cooperstown, New York, USA
2 Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
3 Department of Internal Medicine, Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA; Department of Research & Development, Clinical Epidemiology Unit, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Background & objectives: Clostridium difficile infection is one of the most common healthcare-associated infections worldwide. Recent epidemiologic studies have suggested that statin users may have a lower risk of C. difficile infection, although the results are inconsistent. This meta-analysis was conducted with the aim of summarizing all available data to assess the risk of C. difficile infection among statin users versus non-users.
Methods: A literature review was performed using the MEDLINE and EMBASE databases from inception to October 2017. Cohort, case-control and cross-sectional studies that compared the risk of C. difficile infection among statin users versus non-users were included. Pooled odds ratio (OR) and 95 per cent confidence interval (CI) were calculated using a random-effect, generic inverse variance method.
Results: Six case-control studies and two cross-sectional studies met the eligibility criteria and were included in this meta-analysis. The risk of C. difficile infection among statin users was significantly lower than non-users with the pooled OR of 0.74 (95% CI, 0.61-0.89). The statistical heterogeneity of this study was high (I=90%).
Interpretation & conclusions: This meta-analysis demonstrated a decreased risk of C. difficile infection among statin users versus non-users. Further studies are required to clarify the role of statins for prevention of C. difficile infection in clinical practice.
Dr Karn Wijarnpreecha
One Atwell Road, Cooperstown, NY 13326
|How to cite this article:|
Wijarnpreecha K, Panjawatanan P, Thongprayoon C, Ungprasert P. Statins & risk of Clostridium difficile infection: A meta-analysis.Indian J Med Res 2019;150:359-364
|How to cite this URL:|
Wijarnpreecha K, Panjawatanan P, Thongprayoon C, Ungprasert P. Statins & risk of Clostridium difficile infection: A meta-analysis. Indian J Med Res [serial online] 2019 [cited 2020 Jul 12 ];150:359-364
Available from: http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2019;volume=150;issue=4;spage=359;epage=364;aulast=Wijarnpreecha;type=0