Indian Journal of Medical Research

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 149  |  Issue : 4  |  Page : 548--553

Geographical distribution of primary & secondary dengue cases in India – 2017: A cross-sectional multicentric study


Chaitra Rao1, Harmanmeet Kaur2, Nivedita Gupta2, Sasidharan Pillai Sabeena1, R Ambica3, Amita Jain4, Ashvini Yadav5, Bhagirathi Dwibedi6, Bharti Malhotra7, Dalip K Kakru8, Debasis Biswas5, Deepali Savargaonkar9, M Ganesan10, Jyotsnamayee Sabat6, Kanwardeep Dhingra11, S Lalitha10, Neena Valecha9, Pamireddy Madhavilatha12, Pradip V Barde13, Piyush D Joshi13, Pratibha Sharma7, Rajarshi Gupta14, RK Ratho15, Shailpreet Sidhu11, Shakti Saumnam Shrivastava4, Shanta Dutta14, GB Shantala3, Sheikh Imtiaz8, Shveta Sethi15, Usha Kalawat12, P Vijayachari16, Vimal Raj16, Neetu Vijay2, Biswajyoti Borkakoty17, Purnima Barua18, Tapan Majumdar19, Govindakarnavar Arunkumar1 
1 Manipal Centre for Virus Research, Manipal Academy of Higher Education (Deemed to be University), Manipal, India
2 Indian Council of Medical Research, Department of Health Research, Ministry of Health & Family Welfare, Government of India, Bengaluru, India
3 Department of Microbiology, Bangalore Medical College and Research Institute, Bengaluru, India
4 Department of Microbiology, King George's Medical University, Lucknow, India
5 Department of Microbiology, All India Institute of Medical Sciences, Bhopal, India
6 ICMR-Regional Medical Research Centre, Bhubaneshwar, India
7 Department of Microbiology, Sawai Man Singh Medical College and Attached Hospitals, Jaipur, India
8 Department of Microbiology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India
9 ICMR-National Institute of Malaria Research, New Delhi, India
10 Department of Microbiology, Government Theni Medical College, Theni, India
11 Department of Microbiology, Government Medical College, Amritsar, India
12 Department of Microbiology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India
13 National Institute for Research in Tribal Health, Jabalpur, India
14 ICMR-National Institute of Cholera & Enteric Diseases, Kolkata, India
15 Department of Virology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
16 ICMR-Regional Medical Research Centre, Port Blair, India
17 ICMR-Regional Medical Research Centre, North East Region, Dibrugarh, India
18 Department of Microbiology, Jorhat Medical College, Jorhat, India
19 Department of Microbiology, Agartala Government Medical College, Agartala, India

Correspondence Address:
Dr Govindakarnavar Arunkumar
Manipal Centre for Virus Research, Manipal Academy of Higher Education (Deemed to be University), Manipal 576 104, Karnataka
India

Background & objectives: Dengue virus infection is endemic in India with all the four serotypes of dengue virus in circulation. This study was aimed to determine the geographic distribution of the primary and secondary dengue cases in India. Methods: A multicentre cross-sectional study was conducted at Department of Health Research / Indian Council of Medical Research (DHR)/(ICMR) viral research and diagnostic laboratories (VRDLs) and selected ICMR institutes located in India. Only laboratory-confirmed dengue cases with date of onset of illness less than or equal to seven days were included between September and October 2017. Dengue NS1 antigen ELISA and anti-dengue IgM capture ELISA were used to diagnose dengue cases while anti-dengue IgG capture ELISA was used for identifying the secondary dengue cases. Results: Of the 1372 dengue cases, 897 (65%) were classified as primary dengue and 475 (35%) as secondary dengue cases. However, the proportion varied widely geographically, with Theni, Tamil Nadu; Tirupati, Andhra Pradesh and Udupi-Manipal, Karnataka reporting more than 65 per cent secondary dengue cases while Srinagar, Jammu and Kashmir reporting as low as 10 per cent of the same. The median age of primary dengue cases was 25 yr [interquartile range (IQR 17-35] while that of secondary dengue cases was 23 yr (IQR 13.5-34). Secondary dengue was around 50 per cent among the children belonging to the age group 6-10 yr while it ranged between 20-43 per cent among other age groups. Interpretation & conclusions: Our findings showed a wide geographical variation in the distribution of primary and secondary dengue cases in India. It would prove beneficial to include primary and secondary dengue differentiation protocol in the national dengue surveillance programme.


How to cite this article:
Rao C, Kaur H, Gupta N, Sabeena SP, Ambica R, Jain A, Yadav A, Dwibedi B, Malhotra B, Kakru DK, Biswas D, Savargaonkar D, Ganesan M, Sabat J, Dhingra K, Lalitha S, Valecha N, Madhavilatha P, Barde PV, Joshi PD, Sharma P, Gupta R, Ratho R K, Sidhu S, Shrivastava SS, Dutta S, Shantala G B, Imtiaz S, Sethi S, Kalawat U, Vijayachari P, Raj V, Vijay N, Borkakoty B, Barua P, Majumdar T, Arunkumar G. Geographical distribution of primary & secondary dengue cases in India – 2017: A cross-sectional multicentric study.Indian J Med Res 2019;149:548-553


How to cite this URL:
Rao C, Kaur H, Gupta N, Sabeena SP, Ambica R, Jain A, Yadav A, Dwibedi B, Malhotra B, Kakru DK, Biswas D, Savargaonkar D, Ganesan M, Sabat J, Dhingra K, Lalitha S, Valecha N, Madhavilatha P, Barde PV, Joshi PD, Sharma P, Gupta R, Ratho R K, Sidhu S, Shrivastava SS, Dutta S, Shantala G B, Imtiaz S, Sethi S, Kalawat U, Vijayachari P, Raj V, Vijay N, Borkakoty B, Barua P, Majumdar T, Arunkumar G. Geographical distribution of primary & secondary dengue cases in India – 2017: A cross-sectional multicentric study. Indian J Med Res [serial online] 2019 [cited 2019 Dec 16 ];149:548-553
Available from: http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2019;volume=149;issue=4;spage=548;epage=553;aulast=Rao;type=0