Indian Journal of Medical Research

REVIEW ARTICLE
Year
: 2018  |  Volume : 148  |  Issue : 7  |  Page : 64--70

Postpartum uterine infection & ovarian dysfunction


Sunita Dahiya, Suman Kumari, Payal Rani, Suneel Kumar Onteru, Dheer Singh 
 Molecular Endocrinology, Functional Genomics & System Biology Laboratory, Animal Biochemistry Division, ICAR-National Dairy Research Institute, Karnal, India

Correspondence Address:
Dr Dheer Singh
Molecular Endocrinology, Functional Genomics & System Biology Laboratory, Animal Biochemistry Division, ICAR-National Dairy Research Institute, Karnal 132 001, Haryana
India

Postpartum uterine infections such as metritis, endometritis and mastitis have been considered as underlying causes for ovarian dysfunction in mammals. Almost all mammals, particularly dairy animals are susceptible to postpartum uterine infections, resulting in impaired fertility and economic loss. One of the factors for low fertility in females is ovarian dysfunction, which is exhibited as impaired growth and function of ovarian follicles by the postpartum infection. Immune system of mammals provides a host defence mechanism against pathogenic microbes through the recognition of pathogen-associated molecular patterns (PAMPs) and forming inflammasomes. Like immune cells, ovarian granulosa cells also exhibit a similar pattern of cytokine gene expressions on exposure to PAMPs. Genome-wide transcriptomic approaches explored the molecular mechanisms underlying the immune function of buffalo granulosa cells during endotoxin exposure. Understanding the molecular mechanism of ovarian dysfunction due to uterine infection would be helpful to implement various strategies to handle the adverse effects of postpartum uterine disease on fertility by developing potential therapeutics. Therefore, this article focuses on key factors that are responsible for postpartum infection and particularly summarizes the molecular mechanism of infection underlying the ovarian dysfunction in dairy animals.


How to cite this article:
Dahiya S, Kumari S, Rani P, Onteru SK, Singh D. Postpartum uterine infection & ovarian dysfunction.Indian J Med Res 2018;148:64-70


How to cite this URL:
Dahiya S, Kumari S, Rani P, Onteru SK, Singh D. Postpartum uterine infection & ovarian dysfunction. Indian J Med Res [serial online] 2018 [cited 2019 Aug 21 ];148:64-70
Available from: http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2018;volume=148;issue=7;spage=64;epage=70;aulast=Dahiya;type=0