Indian Journal of Medical Research

REVIEW ARTICLE
Year
: 2018  |  Volume : 148  |  Issue : 6  |  Page : 681--686

Carcinogenicity of smokeless tobacco: Evidence from studies in humans & experimental animals


Saman Warnakulasuriya1, Kurt Straif2 
1 WHO Collaborating Centre for Oral Cancer, King's College London, London, UK
2 Section of Evidence Synthesis and Classification, International Agency for Research on Cancer, Lyon, France

Correspondence Address:
Dr Kurt Straif
Section of Evidence Synthesis & Classification, International Agency for Research on Cancer, World Health Organization, Lyon
France

A Working Group of the Monographs programme of the International Agency for Research on Cancer has classified smokeless tobacco as carcinogenic to humans (Group 1). This review article summarizes the data that support the evaluations of sufficient evidence in humans and in experimental animals for the carcinogenicity of smokeless tobacco whether used alone or with betel quid. It also identifies compounds of smokeless tobacco relevant to carcinogenicity (prominently tobacco-specific nitrosamines) and addiction (nicotine). The epidemiological evidence is summarized for oral cancer, other cancers associated with smokeless tobacco and oral potentially malignant lesions with a focus on analytical studies from the SEARO Region. Studies on cancer in experimental animals are summarized with a focus on studies applying smokeless tobacco products typical for the regions, such as mishri and naswar.


How to cite this article:
Warnakulasuriya S, Straif K. Carcinogenicity of smokeless tobacco: Evidence from studies in humans & experimental animals.Indian J Med Res 2018;148:681-686


How to cite this URL:
Warnakulasuriya S, Straif K. Carcinogenicity of smokeless tobacco: Evidence from studies in humans & experimental animals. Indian J Med Res [serial online] 2018 [cited 2019 May 25 ];148:681-686
Available from: http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2018;volume=148;issue=6;spage=681;epage=686;aulast=Warnakulasuriya;type=0