Indian Journal of Medical Research

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 145  |  Issue : 3  |  Page : 387--394

HIV-malaria interactions in North-East India: A prospective cohort study


Pradhyumn K Mohapatra1, Elsa Pachuau2, Chandra Kumar3, Biswajit Borkakoty1, Eric Zomawia2, Achouba Singh3, Kamini Walia4, Rashmi Arora4, Jagdish Mahanta1, Sarala K Subbarao4 
1 Regional Medical Research Centre (ICMR), Dibrugarh, India
2 Department of Pathology, Civil Hospital, Aizawl, India
3 Department of Community Medicine, Regional Institute of Medical Sciences, Imphal, India
4 Division of Epidemiology & Communicable Diseases, Indian Council of Medical Research, New Delhi, India

Correspondence Address:
Sarala K Subbarao
Division of Epidemiology & Communicable Diseases, Indian Council of Medical Research, V. Ramalingaswamy Bhavan, Ansari Nagar, New Delhi 110 029
India

Background & objectives: The interactions between HIV and malaria co-infection have been shown to influence each other in their clinical outcomes in Sub-Saharan Africa. This study was carried out in the two States of north east India endemic for both HIV and malaria infections, to study the interactions between the two diseases in the HIV-infected population. Methods: In this prospective study, a total of 333 HIV-infected individuals were followed up for a period of 6-18 months in Mizoram and Manipur during 2010-2011. The study assessed the changes in viral load and also the therapeutic efficacy of artesunate plus sulphadoxine-pyrimethamine (AS+SP) combination therapy in HIV-infected and HIV-uninfected individuals with Plasmodium falciparum malaria. Results: Viral load in HIV-infected malaria patients on day zero (D0) ranged from 1110 to 147,000 copies/ml. The log transformation of the geometric means of HIV viral loads revealed no significant difference on different days of follow up. There was 100 per cent adequate clinical and parasitological response (ACPR) after treating with artemisinin based combination therapy (ACT) both in HIV-infected and HIV-uninfected P. falciparum-positive individuals. Similarly, chloroquine showed 100 per cent ACPR in P. vivax HIV-infected individuals. Interpretation & conclusion: The study showed no significant increase in HIV viral load in malaria cases. All HIV-infected and HIV-uninfected P. falciparum malaria-positive cases responded to the treatment with 100 per cent ACPR.


How to cite this article:
Mohapatra PK, Pachuau E, Kumar C, Borkakoty B, Zomawia E, Singh A, Walia K, Arora R, Mahanta J, Subbarao SK. HIV-malaria interactions in North-East India: A prospective cohort study.Indian J Med Res 2017;145:387-394


How to cite this URL:
Mohapatra PK, Pachuau E, Kumar C, Borkakoty B, Zomawia E, Singh A, Walia K, Arora R, Mahanta J, Subbarao SK. HIV-malaria interactions in North-East India: A prospective cohort study. Indian J Med Res [serial online] 2017 [cited 2020 Feb 17 ];145:387-394
Available from: http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2017;volume=145;issue=3;spage=387;epage=394;aulast=Mohapatra;type=0