Indian Journal of Medical Research

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 144  |  Issue : 3  |  Page : 378--384

Exploring the bio-behavioural link between stress, allostatic load & micronutrient status: A cross-sectional study among adolescent boys


Little Flower Augustine1, Krishnapillai Madhavan Nair1, Sylvia Fernandez Rao2, Mendu Vishnu Vardhana Rao3, Punjal Ravinder1, Avula Laxmaiah4 
1 Divisions of Micronutrient Research, National Institute of Nutrition, (ICMR), Hyderabad, India
2 Behavioural Sciences, National Institute of Nutrition, (ICMR), Hyderabad, India
3 Biostatistics, National Institute of Nutrition, (ICMR), Hyderabad, India
4 Community Studies, National Institute of Nutrition, (ICMR), Hyderabad, India

Correspondence Address:
Krishnapillai Madhavan Nair
Division of Micronutrient Research, National Institute of Nutrition (Indian Council of Medical Research), Jamai-Osmania, Hyderabad 500 007, Telangana
India

Background & objectives: Allostatic load (AL) is a cumulative measure of physiological deregulation and is influenced by multiple factors including nutrition. The objectives of the study were to assess AL among adolescent boys (15-19 yr) and delineate its association with psychological stress and micronutrient status. Methods: A cross-sectional, school-based study was conducted among 370 adolescent boys of five higher secondary schools from Hyderabad, India. Perceived stress, adolescent life event stress (ALES), psychological morbidity and coping were measured. Biomarkers of AL included dehydroepiandrosterone sulphate, 12-h urinary cortisol, interleukin-6, C-reactive protein, lipid profile, body mass index and blood pressure. Micronutrient status with respect to iron (haemoglobin, ferritin, hepcidin, soluble transferrin receptor), folate, vitamins B12, C and A were analyzed in a sub-sample of 146 boys. AL score ≥3 was calculated from eight biomarkers. Results: Fourteen per cent participants had no AL but 34.3 per cent had AL score of ≥ 3. Unadjusted means of ALES scores were significantly different (P = 0.045) among participants with low [mean, 95% confidence interval (CI): 580, 531-629] and high (663, 605-721) AL. After controlling for confounders, the means were significantly different for controllable life event sub-scale of ALES (P = 0.048). Adjusted hepcidin concentrations were significantly higher among participants with high AL (means, 95% CI, 27.2, 24.0-30.8 for high AL; 22.1, 20.2-24.2 μg/l for low AL, P = 0.014). Interpretation & conclusions: Build-up of AL was found in adolescent boys and was positively associated with life event stress. Iron nutrition and stress exhibited a positive association through hepcidin. The study provides a link between iron nutrition, physiological deregulation and stress.


How to cite this article:
Augustine LF, Nair KM, Rao SF, Rao MV, Ravinder P, Laxmaiah A. Exploring the bio-behavioural link between stress, allostatic load & micronutrient status: A cross-sectional study among adolescent boys.Indian J Med Res 2016;144:378-384


How to cite this URL:
Augustine LF, Nair KM, Rao SF, Rao MV, Ravinder P, Laxmaiah A. Exploring the bio-behavioural link between stress, allostatic load & micronutrient status: A cross-sectional study among adolescent boys. Indian J Med Res [serial online] 2016 [cited 2019 Oct 21 ];144:378-384
Available from: http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2016;volume=144;issue=3;spage=378;epage=384;aulast=Augustine;type=0