Indian Journal of Medical Research

REVIEW ARTICLE
Year
: 2016  |  Volume : 144  |  Issue : 2  |  Page : 154--168

Angiotensin receptor blockers & endothelial dysfunction: Possible correlation & therapeutic implications


Miroslav Radenkovic, Marko Stojanović, Ivana Milićević Nešić, Milica Prostran 
 Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

Correspondence Address:
Miroslav Radenkovic
Department of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, P. O. Box: 38; 11129 Belgrade
Serbia

The endothelium is one of the most important constituents of vascular homeostasis, which is achieved through continual and balanced production of different relaxing and contractile factors. When there is a pathological disturbance in release of these products, endothelial dysfunction (ED) will probably occur. ED is considered to be the initial step in the development of atherosclerosis. This pathological activation and inadequate functioning of endothelial cells was shown to be to some extent a reversible process, which all together resulted in increased interest in investigation of different beneficial treatment options. To this point, the pharmacological approach, including for example, the use of angiotensin-converting enzyme inhibitors or statins, was clearly shown to be effective in the improvement of ED. One of many critical issues underlying ED represents instability in the balance between nitric oxide and angiotensin II (Ang II) production. Considering that Ang II was confirmed to be important for the development of ED, the aim of this review article was to summarize the findings of up to date clinical studies associated with therapeutic application of angiotensin receptor blockers and improvement in ED. In addition, it was of interest to review the pleiotropic actions of angiotensin receptor blockers linked to the improvement of ED. The prospective, randomized, double-blind, placebo or active-controlled clinical trials were identified and selected for the final evaluation.


How to cite this article:
Radenkovic M, Stojanović M, Nešić IM, Prostran M. Angiotensin receptor blockers & endothelial dysfunction: Possible correlation & therapeutic implications.Indian J Med Res 2016;144:154-168


How to cite this URL:
Radenkovic M, Stojanović M, Nešić IM, Prostran M. Angiotensin receptor blockers & endothelial dysfunction: Possible correlation & therapeutic implications. Indian J Med Res [serial online] 2016 [cited 2017 Apr 29 ];144:154-168
Available from: http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2016;volume=144;issue=2;spage=154;epage=168;aulast=Radenkovic;type=0