Indian Journal of Medical Research

REVIEW ARTICLE
Year
: 2016  |  Volume : 143  |  Issue : 6  |  Page : 696--711

Strategies & recent development of transmission-blocking vaccines against Plasmodium falciparum


Neha Chaturvedi1, Praveen K Bharti2, Archana Tiwari4, Neeru Singh2 
1 National Institute for Research in Tribal Health (ICMR), Jabalpur, School of Biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya (State Technological University of Madhya Pradesh), Bhopal, India
2 National Institute for Research in Tribal Health (ICMR), Jabalpur, India

Correspondence Address:
Neeru Singh
National Institute for Research in Tribal Health (NIRTH), [Formerly Regional Medical Research Centre for Tribals (RMRCT)], NIRTH (ICMR) campus, Nagpur Road, Garha, Jabalpur 482 003, Madhya Pradesh
India

Transmission blocking malaria vaccines are aimed to block the development and maturity of sexual stages of parasite within mosquitoes. The vaccine candidate antigens (Pfs25, Pfs48/45, Pfs230) that have shown transmission blocking immunity in model systems are in different stages of development. These antigens are immunogenic with limited genetic diversity. Pfs25 is a leading candidate and currently in phase I clinical trial. Efforts are now focused on the cost-effective production of potent antigens using safe adjuvants and optimization of vaccine delivery system that are capable of inducing strong immune responses. This review addresses the potential usefulness, development strategies, challenges, clinical trials and current status of Plasmodium falciparum sexual stage malaria vaccine candidate antigens for the development of transmission-blocking vaccines.


How to cite this article:
Chaturvedi N, Bharti PK, Tiwari A, Singh N. Strategies & recent development of transmission-blocking vaccines against Plasmodium falciparum.Indian J Med Res 2016;143:696-711


How to cite this URL:
Chaturvedi N, Bharti PK, Tiwari A, Singh N. Strategies & recent development of transmission-blocking vaccines against Plasmodium falciparum. Indian J Med Res [serial online] 2016 [cited 2019 Jul 18 ];143:696-711
Available from: http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2016;volume=143;issue=6;spage=696;epage=711;aulast=Chaturvedi;type=0