Year : 2015 | Volume
: 141 | Issue : 3 | Page : 375-
Human papillomavirus - Bench to bedside
Dipanwita Banerjee, Partha Basu
Department of Gynecological Oncology, Chittaranjan National Cancer Institute, Kolkata 700 026, West Bengal, India
Department of Gynecological Oncology, Chittaranjan National Cancer Institute, Kolkata 700 026, West Bengal
|How to cite this article:|
Banerjee D, Basu P. Human papillomavirus - Bench to bedside.Indian J Med Res 2015;141:375-375
|How to cite this URL:|
Banerjee D, Basu P. Human papillomavirus - Bench to bedside. Indian J Med Res [serial online] 2015 [cited 2020 Jul 2 ];141:375-375
Available from: http://www.ijmr.org.in/text.asp?2015/141/3/375/156597
Human papillomavirus - Bench to bedside, M. K. Ramνrez-Fort, F. Khan, P. L. Rady, S. K. Tyring, editors (Karger, Basel, Switzerland) 2014. 271 pages, Price: US $ 258.00/CHF 219.00/EUR 183.00
Ever since the discovery of a connection between human papillomavirus (HPV) and skin cancer, the research on this double stranded DNA virus has unfolded many truths about its ability to infect human cells. The virus is responsible for benign, premalignant and malignant lesions of ano-genital region, oro-pharynx and skin. This book aptly highlights the relationship between HPV and the pathological conditions and gives an outline on how to handle the clinical manifestations caused by this virus.
The management of HPV-related diseases often requires a multimodal approach. This book is an excellent source of up - to - date information on human papillomavirus and its various clinical presentations and also the state of the art molecular genomics of the virus. The initial chapters discuss the structure, types and variants and natural history of the virus and elucidate the mechanism of carcinogenesis in human epithelial cells by the virus. Of particular interest is the chapter on host immune response to the virus and the unique features of the virus that allow it to evade the host immunity.
Detailed information on the diagnostic techniques and treatment available feasibility for various cutaneous benign manifestations of the virus and the HPV induced malignancies has been provided. The book unfolds the various treatment options available in correct approach and also gives an outline of the preventive approach towards the virus by the development of vaccine against it. The "difficult to treat" clinical scenarios, especially in immune compromised patients which include transplant recipients as well as HIV - infected individuals have been highlighted which guide us in the best possible approach for the treatment including destructive as well as reconstructive surgeries.
The 19 chapters of the book follow a logical approach from introducing the virus and its present status in taxonomy, to the management of extreme form of this infection i.e. invasive cancer of various parts of the human body in a detailed fashion. It covers both basic sciences and clinical challenges faced in day - to - day practise in a very lucid language, and provides a thorough understanding of how and when to select the best treatment for the widespread disease manifestations caused by this DNA virus. It is well referenced and contains an easy to comprehend index at the end covering all the key words used in the book. However, some of the chapters are quite repetitive and have included similar information, Tables (Table 1 of chapter 1 and Table 1 of chapter 4) and pictures (Figure 1 of chapter 1 and Figure 1 of chapter 4). The chapter on HPV vaccination lacks pertinent information like the safety and effectiveness of the prophylactic vaccines and the recommendations for their use. Now that the vaccines are available and are included in the immunization programmes of more than 50 countries more elaborate information would have benefitted the practitioners.
Overall, this book is well illustrated and presented in a simple language, well supported by plenty of Figures and Tables. It describes recent advances in the field of dermatology and clinical practice and highlights the usefulness of dermoscopy in diagnosis of HPV related diseases. Many eminent physicians of international repute have come together and shared their practical experience even with the description of real cases they handled in their day- to- day practice. This is a an updated source of information for all levels of physicians who come across various cases of HPV infection in their daily practice and may find it useful in management of HPV related diseases. This book will be of use not only to the clinicians but also to the molecular biologists and virologists.