Indian Journal of Medical Research

: 2013  |  Volume : 138  |  Issue : 2  |  Page : 185--193

Obesity & osteoarthritis

Lauren K King1, Lyn March2, Ananthila Anandacoomarasamy3 
1 Sydney Medical School, The University of Sydney, Sydney, Australia
2 Institute of Bone & Joint Research, Kolling Institute of Medical Research, The University of Sydney; Department of Rheumatology, Royal North Shore Hospital, Sydney, Australia
3 Department of Rheumatology, Concord Hospital, Sydney; The University of Sydney, Australia

Correspondence Address:
Ananthila Anandacoomarasamy
Department of Rheumatology, Concord Hospital, Hospital Rd, Concord West, NSW 2138

The most significant impact of obesity on the musculoskeletal system is associated with osteoarthritis (OA), a disabling degenerative joint disorder characterized by pain, decreased mobility and negative impact on quality of life. OA pathogenesis relates to both excessive joint loading and altered biomechanical patterns together with hormonal and cytokine dysregulation. Obesity is associated with the incidence and progression of OA of both weight-bearing and non weight-bearing joints, to rate of joint replacements as well as operative complications. Weight loss in OA can impart clinically significant improvements in pain and delay progression of joint structural damage. Further work is required to determine the relative contributions of mechanical and metabolic factors in the pathogenesis of OA.

How to cite this article:
King LK, March L, Anandacoomarasamy A. Obesity & osteoarthritis.Indian J Med Res 2013;138:185-193

How to cite this URL:
King LK, March L, Anandacoomarasamy A. Obesity & osteoarthritis. Indian J Med Res [serial online] 2013 [cited 2020 Jul 10 ];138:185-193
Available from:;year=2013;volume=138;issue=2;spage=185;epage=193;aulast=King;type=0