Indian Journal of Medical Research

REVIEW ARTICLE
Year
: 2011  |  Volume : 134  |  Issue : 4  |  Page : 419--431

An insight into the drug resistance profile & mechanism of drug resistance in Neisseria gonorrhoeae


Achchhe Lal Patel1, Uma Chaudhry1, Divya Sachdev1, Poonam Nagpal Sachdeva1, Manju Bala2, Daman Saluja1 
1 Dr B.R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi, India
2 Regional STD Teaching Training & Research Centre, Vardhman Mahavir Medical College & Safdarjang Hospital, New Delhi, India

Correspondence Address:
Daman Saluja
Dr B.R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi 110 007
India

Among the aetiological agents of treatable sexually transmitted diseases (STDs), Neissseria gonorrhoeae is considered to be most important because of emerging antibiotic resistant strains that compromise the effectiveness of treatment of the disease - gonorrhoea. In most of the developing countries, treatment of gonorrhoea relies mainly on syndromic management rather than the aetiological based therapy. Gonococcal infections are usually treated with single-dose therapy with an agent found to cure > 95 per cent of cases. Unfortunately during the last few decades, N. gonorrhoeae has developed resistance not only to less expensive antimicrobials such as sulphonamides, penicillin and tetracyclines but also to fluoroquinolones. The resistance trend of N. gonorrhoeae towards these antimicrobials can be categorised into pre-quinolone, quinolone and post-quinolone era. Among the antimicrobials available so far, only the third-generation cephalosporins could be safely recommended as first-line therapy for gonorrhoea globally. However, resistance to oral third-generation cephalosporins has also started emerging in some countries. Therefore, it has become imperative to initiate sustained national and international efforts to reduce infection and misuse of antibiotics so as to prevent further emergence and spread of antimicrobial resistance. It is necessary not only to monitor drug resistance and optimise treatment regimens, but also to gain insight into how gonococcus develops drug resistance. Knowledge of mechanism of resistance would help us to devise methods to prevent the occurrence of drug resistance against existing and new drugs. Such studies could also help in finding out new drug targets in N. gonorrhoeae and also a possibility of identification of new drugs for treating gonorrhoea.


How to cite this article:
Patel AL, Chaudhry U, Sachdev D, Sachdeva PN, Bala M, Saluja D. An insight into the drug resistance profile & mechanism of drug resistance in Neisseria gonorrhoeae.Indian J Med Res 2011;134:419-431


How to cite this URL:
Patel AL, Chaudhry U, Sachdev D, Sachdeva PN, Bala M, Saluja D. An insight into the drug resistance profile & mechanism of drug resistance in Neisseria gonorrhoeae. Indian J Med Res [serial online] 2011 [cited 2020 Apr 6 ];134:419-431
Available from: http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2011;volume=134;issue=4;spage=419;epage=431;aulast=Patel;type=0