Indian Journal of Medical Research

BOOK REVIEW
Year
: 2011  |  Volume : 133  |  Issue : 1  |  Page : 123--124

Mechanisms of microbial pathogenesis


Jagdish Chander 
 Department of Microbiology, Government Medical College Hospital, Sector 32, Chandigarh 160 030, India

Correspondence Address:
Jagdish Chander
Department of Microbiology, Government Medical College Hospital, Sector 32, Chandigarh 160 030
India




How to cite this article:
Chander J. Mechanisms of microbial pathogenesis.Indian J Med Res 2011;133:123-124


How to cite this URL:
Chander J. Mechanisms of microbial pathogenesis. Indian J Med Res [serial online] 2011 [cited 2020 Mar 30 ];133:123-124
Available from: http://www.ijmr.org.in/text.asp?2011/133/1/123/76716


Full Text

Mechanisms of microbial pathogenesis, D. Raghunath, V. Nagaraja, editors [Macmillan (India) Pvt. Ltd., Bangalore] 2010. 242 pages. Price: Rs.685.00

There are significant developments entailing rapid progress in microbiology and infectious diseases over the past few decades. With the increase in immunocompromised conditions, it is essential to know about microbial pathogenesis of infection in more details. Infections like Japanese encephalitis, dengue, chikungunya, avian and swine flu are presenting with larger magnitude in their worst forms. Malaria is now presenting with high morbidity and mortality with multi-organ failure, a feature that was not seen in the past. Emergence of newer strains and the more recent outbreaks of cholera in the Latin America, after a gap of almost a century, have posed serious questions before the scientific community about understanding of disease process. Therefore, it is pertinent to grasp all possible aspects of microbial pathogenesis.

This book on "Mechanisms of Microbial Pathogenesis" has been nicely compiled by Drs D. Raghunath and V. Nagaraja and contains collection of papers presented at the Tenth Sir Dorabji Tata Symposium held from March 10-12, 2009 at the Indian Institute of Science, Bangalore, coinciding with its centenary celebrations.

The book is tenth in its series wherein topics pertaining to research in tropical diseases are being dealt threadbare. The contents of the book provide topics covered during the deliberations of the Symposium along with profiles of speakers/authors. In the beginning, the book provides authors' profile covering their area of research activity. Each speaker highlighted the research effort to elucidate the virulence mechanisms of the chosen organisms. The abstracts of award winning posters presented by young and budding scientists are given at the end.

The topics dealt with in the book are of contemporary importance when many organisms are emerging and some of them are re-emerging in Indian scenario. These have not limited to Indian subcontinent but having a significant global impact to an extent that some of these are pandemic in nature. The basic goal of compilation of these lectures is to gain deeper insights of the various paradigms of pathogeneses. Each one of the organisms, belonging to any of the category of virus, bacteria or eukaryotes manoeuvres function of the host thereby contributing significantly to its pathogenesis. The way these evade host defence system, cross cellular and immunological barriers, manipulate host machinery for their propagation and thereby subvert the host functions to cause infections, is simply amazing. In due course of time, obviously each organism has developed its own mechanism and in many cases they come with new modalities. Many of these induce the host factors to collaborate in their effort for successful survival while residing inside the host itself.

The organisms covered have a wide spectrum like Mycobacterium, the significant bacterial pathogens like Salmonella, Shigella, Neisseria meningitidis and Helicobacter pylori. The eukaryotes like Plasmodium and Candida species have been covered. A wide variety of viruses has been dealt with like enteroviruses focussing on polio, flaviviruses like dengue and Japanese B encephalitis virus, rhabdovirus and hepatitis C, E virus. Substantial coverge has been given to Mycobacterium tuberculosis considering its importance as the most formidable pathogen. The first three sessions were entirely devoted to various issues on tuberculosis. M. tuberculosis being important part of book, has been dedicated to Prof. T. Ramakrishnan, who was pioneer in the research on tuberculosis. His contribution particularly understanding transduction in Mycobacterium species and mechanisms of action of the drugs like isoniazid and streptomycin, has been duly acknowledged.

The next three sessions were devoted to viral infections covering Japanese B encephalitis from basic research to therapeutic intervention, the pathogenesis of dengue haemorrhagic fever. The possible structural and regulatory functions during viral pathogenesis, i.e. ORF3 protein of hepatitis E virus have been highlighted. The enterovirus (i.e. poliovirus) on threshold of its eradication, has been aptly elucidated. The next two sessions were on the bacterial infections, one of these was merged with fungal infections, i.e. candidiasis, mainly on the anti-Candida drug targets. The last session was on malaria emphasising on anti-malarial targets.

The presentations compiled in this book will provide opportunity stimulating future research in the field of microbial pathogenesis. The collection would generate interest among present as well as prospective workers in the field of microbial pathogenesis of a variety of infections. The book will be very helpful for students, young researchers, in addition to scientists and clinicians working in infectious diseases. The overall get-up of the book is attractive with high quality paper, and there are no typographical errors in the text. To put in nutshell, this book has come out as one of the ideal books in the field of microbiology for the students pursuing their understanding in mechanisms of microbial pathogenesis.